37859-42-0Relevant articles and documents
A highly selective naked-eye and fluorescent probe for fluoride ion based on 1,8-naphalimide and benzothizazole
Chen, Xiaoxing,Leng, Taohua,Wang, Chengyun,Shen, Yongjia,Zhu, Weihong
, p. 299 - 305 (2017)
Based on benzothizazole and 1,8-naphalimide, a novel colorimetric and fluorescent probe (probe 1) for fluoride ion was synthesized by Schiff base reaction. The striking yellow-to-blue color change of the probe 1 in the CH3CN was observed with the naked eyes only in presence of F? among the eight anions (F?, Cl?, Br?, I?, NO3?, HSO4?, H2PO4?, AcO?). Besides that, upon addition of F?, both of the absorption and emission peaks shifted to near-infrared region (NIR) (>600?nm) in UV–vis and fluorescent spectra, and the detection limit reached as low as 0.41?μM. Furthermore, the 1H NMR titration and theoretical calculation based on TD-DFT indicated that the fluoride ion induced deprotonation of the probe 1 through hydrogen bonding interaction between amino group of probe 1 and fluoride ion.
[1,3]-Claisen rearrangement via removable functional group mediated radical stabilization
Alam, Md Nirshad,Dash, Soumya Ranjan,Mukherjee, Anirban,Pandole, Satish,Marelli, Udaya Kiran,Vanka, Kumar,Maity, Pradip
, p. 890 - 895 (2021/02/01)
A thermal O-to-C [1,3]-rearrangement of α-hydroxy acid derived enol ethers was achieved under mild conditions. The 2-aminothiophenol protection of carboxylic acids facilitates formation of the [1,3] precursor and its thermal rearrangement via stabilization of a radical intermediate. Experimental and theoretical evidence for dissociative radical pair formation, its captodative stability via aminothiophenol, and a unique solvent effect are presented. The aminothiophenol was deprotected from rearrangement products as well as after derivatization to useful synthons.
Visible light-induced hydroxyalkylation of 2H-benzothiazoles with alcohols via selectfluor oxidation
Kong, Yaolei,Xu, Wenxiu,Liu, Xinghai,Weng, Jianquan
supporting information, p. 3245 - 3249 (2020/06/21)
A visible-light induced metal-free approach was described for the hydroxyalkylation of 2H-benzothiazoles with alcohols by using selectfluor as the oxidant. A variety of 2H-benzothiazoles and alcohols could be tolerated, providing a mild and simple method for the synthesis of C2-hydroxyalkylated 2H-benzothiazoles in moderate to good yields. Besides, ethers were also compatible in this reaction, leading to corresponding C2 ether-substituted 2H-benzothiazoles with high regioselectivity.
TRANSGLUTAMINASE 2 (TG2) INHIBITORS
-
Paragraph 00778, (2020/03/02)
Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit transglutaminase 2 (TG2). Also described herein are methods for using such TG2 inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from TG2 inhibition.
