3787-09-5Relevant articles and documents
Synthesis and characterization of dialkyl esters of 1,2,4,5-tetrazine-3,6- dicarboxylic acid
Frebort, Stepan,Almonasy, Numan,Hrdina, Radim,Lycka, Antonin,Lisa, Miroslav,Holcapek, Michal
, p. 107 - 115 (2008)
Synthesis and characterization of a series of dialkyl esters of 1,2,4,5-tetrazine-3,6-dicarboxylic acid are reported. These compounds were prepared by a two-stage synthesis: re-esterification of dimethyl 1,4-dihydro-1,2,4,5-tetrazine-3,6-dicarboxylate in the presence of aluminium triethoxide and subsequent dehydrogenation of dialkyl 1,4-dihydro-1,2,4,5- tetrazine-3,6-dicarboxylates. The structures of the prepared compounds were confirmed by NMR and mass spectra.
Copper-Free Click Reaction Sequence: A Chemoselective Layer-by-Layer Approach
Meinecke, Jannick,Koert, Ulrich
supporting information, p. 7609 - 7612 (2019/10/02)
An additive-free chemoselective ligation of dual clickable building blocks is demonstrated. The challenge of balancing reactivity and stability was achieved by employing a small, electron-deficient tetrazine bearing an azido group and an enol ether functionalized cyclooctyne. The chemoselective sequence of strain-promoted azide-alkyne cycloaddition (SPAAC) and inverse-electron-demand Diels-Alder (IEDDA) reaction is demonstrated with a cholic acid derived triazide as a molecular surface model for layer-by-layer synthesis.
A Detailed, Convenient Preparation of Dimethyl 1,2,4,5-Tetrazine-3,6-dicarboxylate
Boger, Dale L.,Coleman, Robert S.,Panek, James S.,Huber, F. X.,Sauer, J.
, p. 5377 - 5379 (2007/10/02)
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