3800-06-4

Basic information

• Product Name: 2-Amino-4'-fluorobenzophenone
• Synonyms: 2-AMINO-4'-FLUOROBENZOPHENONE;(2-AMINO-4'-FLUORO-PHENYL)-PHENYL-METHANONE;(2-AMINO-PHENYL)-(4-FLUORO-PHENYL)-METHANONE;METHANONE, (2-AMINOPHENYL)(4-FLUOROPHENYL);2-[(4-fluorophenyl)carbonyl]aniline;2-AMinophenyl 4-Fluorophenyl Ketone;o-(p-Fluorobenzoyl)aniline;(2-Aminophenyl)(4-fluorophenyl)methanone, 2-(4-Fluorobenzoyl)aniline
• CAS NO: 3800-06-4
• Molecular Formula: C₁₃H₁₀FNO
• Molecular Weight: 215.22
• EINECS: 1592732-453-0
• Product Categories: Aromatic Benzophenones & Derivatives (substituted);API intermediates;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Pitavastatin Calcium Intermediates
• Mol File: 3800-06-4.mol
• Article Data: 30

Chemical Properties

• Melting Point: 122-128°C
• Boiling Point: 390.559 °C at 760 mmHg
• Flash Point: 190.004 °C
• Appearance: /
• Density: 1.237 g/cm³
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• PKA: -0.19±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-4'-fluorobenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4'-fluorobenzophenone(3800-06-4)
• EPA Substance Registry System: 2-Amino-4'-fluorobenzophenone(3800-06-4)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 3800-06-4(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

An intermediate in the preparation of the anticholesteremic Pitavastatin.

Upstream product

• 120303-62-0 (4-fluorophenyl)(2-nitrophenyl)methanone 
• 934560-46-0 N-[2-(4-fluorobenzoyl)phenyl]-4-methylbenzenesulfonamide 
• 1548-28-3 2-<4-Fluor-benzoyl>-benzamid 
• 1194-02-1 4-fluorobenzonitrile 
• 62-53-3 aniline 
• 133776-41-7 anthranilic acid N-methoxy-N-methylamide 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 118-48-9 isatoic anhydride 
• 462-06-6 fluorobenzene 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 51012-30-7 2-(4-Fluoro-benzenesulfonylamino)-benzoic acid 
• 88-72-2 1-methyl-2-nitrobenzene 
• 134-20-3 2-carbomethoxyaniline 
• 352-13-6 4-flourophenylmagnesium bromide 

Downstream Products

• 121659-64-1 Ethyl 4-(4'-fluorophenyl)-2-(1'-methylethyl)-quinolin-3-yl-carboxylate 
• 674802-91-6 4-(aminosulfonyl)-N-[2-(4-fluorobenzoyl)phenyl]benzamide 
• 96883-69-1 N-[2-(4-fluoro-benzoyl)-phenyl]-isonicotinamide 
• 1026902-78-2 N-[2-(4-fluoro-benzoyl)-phenyl]-2-pyridin-4-yl-acetamide 
• 872323-67-6 N₂-acetyl-N₁-[2-(4-fluorobenzoyl)phenyl]glycinamide 
• 1246763-14-3 4-(4'-fluorophenyl)quinazoline 
• 1229609-91-9 4-(4-fluoro-phenyl)-2-phenyl-quinazoline 

Relevant articles and documents

Rapid construction of cyclopenta[: B] naphthalene frameworks from propargylic alcohol tethered methylenecyclopropanes

We have developed a new synthetic methodology for the rapid construction of cyclopenta[b]naphthalene frameworks from the reaction of propargylic alcohol tethered methylenecyclopropanes with mesyl chloride in the presence of triethylamine through cascade cyclization. The reaction can be performed under mild conditions without the use of transition metals, affording the target products in moderate to good yields, and this cyclization reaction process can be scaled up to a gram-scale synthesis.

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration

An unprecedented deoxygenative arylation of aromatic carboxylic acids has been achieved, allowing the construction of an enhanced library of unsymmetrical diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chemistry allows for precise cleavage of a stronger C?O bond and formation of a weaker C?C bond by 1,5-aryl migration under mild reaction conditions. This new protocol is independent of substrate redox-potential, electronic, and substituent effects. It affords a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields.

Synthetic method for 2-amino-4'-fluoro-benzophenone

The invention discloses a synthetic method for 2-amino-4'-fluoro-benzophenone. The method comprises the following steps: subjecting o-toluidine and tosyl chloride to an amidation reaction to obtain 4-methyl-N-(2-methylphenyl) benzenesulfonamide; then performing chlorination by a chlorine gas, producing a Friedel-Crafts reaction with fluorobenzene, and obtaining N-(2-(4-fluorobenzoyl)phenyl)-4-toluenesulfonamide; and finally obtaining the 2-amino-4'-fluoro-benzophenone by deprotection of concentrated sulfuric acid. The synthetic method is cheap and easily available in starting material, is lowin cost, is convenient to operate, is suitable for industrial production, is green and environmentally friendly in synthetic route, and is high in yield, and the purity of the 2-amino-4'-fluoro-benzophenone obtained by preparation is good.