381-72-6

Basic information

• Product Name: 2,2-DIFLUOROACETYL CHLORIDE
• Synonyms: DIFLUOROACETYL CHLORIDE;2,2-DIFLUOROACETYL CHLORIDE;2,2-DIFLUOROACETYL CHLORIDE, 97% MIN.
• CAS NO: 381-72-6
• Molecular Formula: C₂HClF₂O
• Molecular Weight: 114.48
• Mol File: 381-72-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 25°C
• Flash Point: °C
• Appearance: /
• Density: 1,1 g/cm3
• Vapor Pressure: 790mmHg at 25°C
• Refractive Index: 1.327
• Storage Temp.: Keep Cold
• CAS DataBase Reference: 2,2-DIFLUOROACETYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIFLUOROACETYL CHLORIDE(381-72-6)
• EPA Substance Registry System: 2,2-DIFLUOROACETYL CHLORIDE(381-72-6)

Safety Data

• Hazard Codes: C
• Statements: 20/21/22-35
• Safety Statements: 23-26-36/37/39
• RIDADR: 3265
• HazardClass: KEEP COLD, CORROSIVE
• Hazardous Substances Data: 381-72-6(Hazardous Substances Data)

Usage

General Description

2,2-Difluoroacetyl chloride is a chemical compound with the formula C4H4ClF2O. It is a colorless liquid with a pungent odor and is primarily used as an intermediate in the pharmaceutical industry for the synthesis of various drugs and agrochemicals. 2,2-DIFLUOROACETYL CHLORIDE is a powerful acylating agent and is widely utilized in the production of fluorine-containing organic compounds. Additionally, it is also used in the manufacture of agricultural chemicals, plastics, and rubber. However, 2,2-Difluoroacetyl chloride is highly corrosive and toxic, and should be handled with extreme care and appropriate safety measures.

InChI:InChI=1/C2HClF2O/c3-1(6)2(4)5/h2H

Upstream product

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• 1421518-24-2 N-(2-((4,6-dimorpholino-1,3,5-triazin-2-yl)amino)-5-methoxyphenyl)-2,2-difluoroacetamide 
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Relevant articles and documents

PROCESS AND INTERMEDIATE FOR THE MANUFACTURE OF DIFLUOROACETYL CHLORIDE

The present invention concerns a process and intermediates for the manufacture of difluoro acetyl chloride. The invention further concerns a process for the manufacture of an agrochemically or pharmaceutically active compound, which comprises the process and intermediate for the manufacture of difluoro acetyl chloride for the manufacture of difluoro acetyl chloride or its intermediate.

TRANSFORMATION D'OXYDES D'ALKYLES ET DE POLYFLUOROALKYLES PAR LES ACIDES DE LEWIS. INFLUENCE DES RADICAUX ALKYLES.

The generation of perfluoroalkanoyl fluorides from perfluoroalkyl ethers by Lewis acids RHOCF2RF -> FRH + RFCOF depends mainly upon the nature of the alkyl RH radical.It is necessary to use RH groups with donor character and also electrophilic groups present on the radicals can facilitate the breaking of the RH-O bond.As examples, ethers with Me3SiCH2CH2 or CH2=CH-CH2 groups allowed reactions to occur readily at room temperature or below using common Lewis acids such as ZnCl2, BF3-Et2O, AlCl3.