564-10-3Relevant articles and documents
-
Pavlov,V.M. et al.
, (1971)
-
Preparation method of 1,1,3,3,3-pentafluoropropylene
-
Paragraph 0033-0038, (2019/04/27)
The invention discloses a preparation method of 1,1,3,3,3-pentafluoropropylene. The preparation method comprises the following steps: (1) carrying out a reaction on halgen-containing inorganic salt and sevofluoroisobutenyl methyl ether in a first aprotic solvent, adding water into the solution to stir, cool and filter after the reaction, and rectifying the filtrate to obtain hexafluoroisobutyric acid; and (2) carrying out a reaction on the hexafluoroisobutyric acid obtained in the step (1) and a hydrogen ion capturing agent, collecting a generated gas phase product and cooling the product to obtain the 1,1,3,3,3-pentafluoropropylene product. The preparation method has the advantages of being simple in process, environment-friendly, low in cost and green and environment-friendly.
Synthesis of 3,3,3-trifluoroethyl isocyanate, carbamate and ureas. Anticancer activity evaluation of N-(3,3,3-trifluoroethyl)-N′-substituted ureas
Luzina, Elena L.,Popov, Anatoliy V.
, p. 82 - 88 (2015/06/25)
A new method is described for producing 3,3,3-trifluoroethyl isocyanate from perfluoroisobutene (PFIB). Isocyanate was used for synthesis of carbamates and ureas. A series of trifluoroethyl-substituted ureas has been tested in the National Cancer Institute (NCI, Bethesda, USA) by the NCI-60 DTP Human Tumor Cell Line Screening Program at a single high dose (10-5 M). The moderate anticancer activity was shown against some types of cancer on the individual human cell lines for leukemia, non-small cell lung cancer and renal cancer.
Chemoselective halogenation of 2-hydroperfluoroalkyl aldehydes
Wiebe, Donald A.,Burton, Donald J.
experimental part, p. 4 - 11 (2012/07/13)
2-Hydroaldehydes, RfCH(R)CHO, where Rf = CF 3, C2F5, n-C3F7 and R = CF3, C2F5, n-C3F7, Ph, H, were prepared via acid hydrolysis of the corresponding vinyl ethers, R fC(R) = CHOCH3, which can be readily prepared by reaction of Ph3P+C?HOCH3 with the corresponding ketone. The 2-hydroaldehydes can be chemoselectively converted to the acyl halide, RfCH(R)C(O)X (X = Cl, Br), via free-radical halogenation. The perfluoroalkyl group deactivates the 2-position toward radical abstraction of the 2-hydrogen, and halogenation occurs exclusively at the formyl hydrogen. However, halogenations of the 2-hydroaldehydes in glacial acetic acid chemoselectively gives the 2-haloaldehydes, RfCX(R)CHO, X = Cl, Br. Hydrolysis of the 2-hydroperfluoroacyl halides provides a useful route to 2-hydroperfluoroalkyl branched carboxylic acids, useful ketene precursors. This route avoids the use of toxic fluoroolefins, such as perfluoroisobutylene.
