383-70-0

Basic information

• Product Name: N-(Trifluoroacetyl)glycine
• Synonyms: TRIFLUOROACETYL GLYCINE;n-(trifluoroacetyl)glycine;N-ALPHA-TRIFLUOROACETYL-GLYCINE;TFA-GLYCINE;TFA-GLY-OH;[(Trifluoroacetyl)amino]acetic acid;glycine,N-(trifluoroacetyl)-;N-alpha-Trifluoracetyl-glycin
• CAS NO: 383-70-0
• Molecular Formula: C₄H₄F₃NO₃
• Molecular Weight: 171.07
• Product Categories: Amino Acids;Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives
• Mol File: 383-70-0.mol
• Article Data: 24

Chemical Properties

• Melting Point: 120-121 °C
• Boiling Point: 291.6°C
• Flash Point: 130°C
• Appearance: white solid
• Density: 1.534
• Vapor Pressure: 0.000479mmHg at 25°C
• Refractive Index: 1.386
• Storage Temp.: 2-8°C
• Solubility: Chloroform, DMSO
• PKA: 2.99±0.10(Predicted)
• CAS DataBase Reference: N-(Trifluoroacetyl)glycine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(Trifluoroacetyl)glycine(383-70-0)
• EPA Substance Registry System: N-(Trifluoroacetyl)glycine(383-70-0)

Safety Data

• Hazardous Substances Data: 383-70-0(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

N-Trifluoroacetylglycine (cas# 383-70-0) is a compound useful in organic synthesis.

InChI:InChI=1/C4H4F3NO3/c5-4(6,7)3(11)8-1-2(9)10/h1H2,(H,8,11)(H,9,10)

Upstream product

• 56-40-6 glycine 
• 407-25-0 trifluoroacetic anhydride 
• 354-32-5 trifluoracetyl chloride 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 848860-95-7 S-dodecyl trifluorothioacetate 
• 383-63-1 ethyl trifluoroacetate, 
• 500-73-2 phenyl trifluoroacetate 
• 383-64-2 S-ethyl trifluoroacetate 

Downstream Products

• 2821-48-9 N-trifluoroacetyl-glycine-(N'-trityl-hydrazide) 
• 370-34-3 N-trifluoroacetyl-thioglycine S-phenyl ester 
• 370-33-2 N-trifluoroacetyl-glycine anilide 
• 785-71-7 N-trifluoroacetyl-glycine phenyl ester 
• 687-04-7 N-trifluoroacetylglycine vinyl ester 
• 90476-40-7 [(2-{Benzyl-[2-(2,2,2-trifluoro-acetylamino)-acetyl]-amino}-2-phenyl-acetylamino)-methyl]-phosphonic acid diethyl ester 
• 284036-92-6 methyl (benzyl 4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-(N-trifluoroacetylglycylamido)-D-glycero-α-D-galacto-2-nonulopyranosid)onate 
• 82706-23-8 (E)-But-2-en-1-yl 2-(2,2,2-trifluoroacetamido)acetate 
• 142370-00-1 ((C₆H₅)3P)2Pt(CF₃C(O)NCH₂COO) 
• 3397-30-6 2-(2,2,2-trifluoroacetamido)acetic acid succinimidyl ester 
• 4554-41-0 N-trifluoroacetyl-glycinyl-L-phenylalanine methyl ester 
• 1599422-98-6 N-(trifluoroacetyl)glycine {N-benzyl-N-[4-tert-butyldimethylsilyloxy-(2E)-buten-1-yl]}amide 
• 1301701-44-9 (E)-2-phenylbut-2-enyl 2-(2,2,2-trifluoroacetamido)acetate 
• 1275611-24-9 C₃₈H₃₅F₃N₄O₁₀ 

Relevant articles and documents

N-TFA-Gly-Bt-based stereoselective synthesis of substituted 3-amino tetrahydro-2 h-pyran-2-ones via an organocatalyzed cascade process

Chiral-substituted 3-amino tetrahydro-2H-pyran-2-ones were prepared in excellent enantioselectivities (up to 99percent ee) via an organo-catalyzed cascade procedure with N-TFA-Gly-Bt and α,β-unsaturated aldehydes as the substrates. The corresponding tetra

BF3·OEt2-TFAA Mediated Tetra-Functionalization of Amino Acids-Synthesis of Di-and Tri-Substituted 2-Trifluoromethyl Oxazoles in One Pot

A highly efficient, TFAA-BF3·OEt2 mediated multicomponent coupling of amino acid, TFAA, and aromatics provides a broad library of 2-Trifluoromethyl equipped 2,5-disubstituted/2,4,5-Trisubstituted oxazoles or N-(trifluoroacetyl)-β-Aminoalkyl ketones. This amino acid tetra-functionalization approach involves amidation (C-N), anhydride (C-O), Friedel-Crafts acylation (C-C), and Robinson-Gabriel annulation (C-O) followed by dehydrative aromatization. This reaction takes place under operationally simple, mild, and metal-free conditions using readily available amino acids and aromatic compounds.

SYNTHESIS OF (2S,3R,4R)-4,5-DIHYDROXYISOLEUCINE AND DERIVATIVES

The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diastereomer mix by acylase, and subsequent Sharpless dihydroxylation of the resulting 2-amino-3-methylpent-4-enoicacid derivative.

The: Ortho -substituent on 2,4-bis(trifluoromethyl)phenylboronic acid catalyzed dehydrative condensation between carboxylic acids and amines

2,4-Bis(trifluoromethyl)phenylboronic acid is a highly effective catalyst for dehydrative amidation between carboxylic acids and amines. Mechanistic studies suggest that a 2:2 mixed anhydride is expected to be the only active species, and the ortho-substituent of boronic acid plays a key role in preventing the coordination of amines to the boron atom of the active species, thus accelerating the amidation. This catalyst works for α-dipeptide synthesis.