38790-07-7

Basic information

• Product Name: 1,2-Benzenediol, 5-bromo-3-methoxy-
• Synonyms: 1,2-Benzenediol, 5-bromo-3-methoxy-
• CAS NO: 38790-07-7
• Molecular Formula: C₇H₇BrO₃
• Molecular Weight: 0
• Mol File: 38790-07-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-Benzenediol, 5-bromo-3-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzenediol, 5-bromo-3-methoxy-(38790-07-7)
• EPA Substance Registry System: 1,2-Benzenediol, 5-bromo-3-methoxy-(38790-07-7)

Safety Data

• Hazardous Substances Data: 38790-07-7(Hazardous Substances Data)

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.

Explanation

1,2-Benzenediol, 5-bromo-3-methoxyis derived from catechol, a natural phenol and antioxidant.

Explanation

The chemical structure describes the arrangement of atoms and functional groups in the molecule.

Explanation

It is used to study the function of various enzymes and proteins, particularly those involved in oxidative stress and tissue damage.

Explanation

1,2-Benzenediol, 5-bromo-3-methoxyis used as a starting material or intermediate in the synthesis of pharmaceuticals and agrochemicals.

Explanation

The compound has potential applications in the development of new drugs for the treatment of various medical conditions, including cancer and neurodegenerative diseases.

Explanation

The solubility of the compound in different solvents is not provided in the given material.

Explanation

Information about the stability of the compound under various conditions is not provided in the given material.

Explanation

The reactivity of the compound with other substances or under specific conditions is not provided in the given material.

Explanation

Information about the toxicity of the compound is not provided in the given material.

Derivative of catechol

Yes

Chemical structure

Contains a benzene ring with two hydroxyl groups at the 1 and 2 positions, a bromine atom at the 5 position, and a methoxy group at the 3 position.

Biochemical research tool

Yes

Applications in synthesis

Pharmaceutical and agrochemical industries

Potential medical applications

Treatment of cancer and neurodegenerative diseases

Solubility

Not mentioned in the material

Stability

Not mentioned in the material

Reactivity

Not mentioned in the material

Toxicity

Not mentioned in the material

Upstream product

• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 5034-74-2 5-bromo-3-methoxysalicylaldehyde 

Downstream Products

• 91511-83-0 5-bromo-7-methoxy-1,3-benzodioxol 
• 1259015-03-6 C₇H₅BrO₃ 
• 2675-79-8 1-bromo-3,4,5-trimethoxybenzene 
• 38790-11-3 2,3',4',5'-Tetramethoxy-diphenylether-4-carbonsaeure-methylester 
• 484-28-6 cotarnone 
• 109856-96-4 6-chloroethyl-2-methoxy-3,4-methylenedioxybenzaldehyde 
• 109856-89-5 5-chloroethyl-1-methoxy-2,3-methylenedioxybenzene 
• 109856-87-3 2-(3-methoxy-4,5-methylenedioxyphenyl)ethanol 
• 484-30-0 4-Methoxy-1,3-dioxolo<4,5-g>7,8-dihydroisochinolin 
• 208193-00-4 Triisopropyl-[(S)-4-(7-methoxy-benzo[1,3]dioxol-5-yl)-cyclohex-1-enyloxy]-silane 
• 208192-99-8 4-(7-Methoxy-benzo[1,3]dioxol-5-yl)-cyclohexanone 

Relevant articles and documents

Synthetic method 5 - bromo -1 and 2,3 - trimethoxy benzene

The synthesis method of 5 -bromo -1-2,3 -methoxy benzene comprises the following steps: S1, taking the vanillin as a starting raw material, and brominating 5 - bromo -2 - hydroxyl -3 -methoxybenzaldehyde through the hydroxyl group para-position. S2 is obt

Chemoenzymatic Formal Total Synthesis of Pancratistatin from Narciclasine-Type Compounds via Myers Transposition: Model Study for a Short Conversion of Narciclasine to Pancratistatin

A formal total synthesis of pancratistatin was accomplished by conversion of advanced intermediates, used in the synthesis of narciclasine, to pancratistatin precursors via Myers' reductive transposition as the key strategic step. The synthesis began with the whole cell fermentation of m -dibromobenzene with JM109(pDTG601a), a recombinant strain that over-expresses toluene dioxygenase, which provided the corresponding cis -dihydrodiol 16 as a single isomer with complete optical purity. The key reductive transposition of the allylic alcohol 8a to olefin 9a allowed for further installation of the C-1/C-2 trans -diol, required for the pancratistatin scaffold, through the introduction of a cyclic sulfate and its subsequent opening. The formal synthesis of pancratistatin was accomplished in 14 steps (12 operations) from commercially available m -dibromobenzene. Experimental and spectral data are provided for all new compounds.

Application of the β-azidonation reaction to the synthesis of the antitumor alkaloid (+)-pancratistatin

o-Vanillin 21 was converted into 24 following literature procedures. Treatment of 24 with n-BuLi/THF followed by addition of 25 gave 26. Dehydration (POCL3/pyridine/DBU), hydrogenation and hydrolysis of 26 gave the ketone 29. Chirality was introduced by deprotonation of 29 with the lithium salt of (+)-bis(αmethylbenzyl)amine, followed by triisopropylsilyl trifluoromethanesulfonate to give 30 (95%). β-Azidonation of 30 with (PhiO)n/TMSN3 rapidly produced 31 (95%) as a mixture of trans- and cis- diastereomers in a 3.5:1 ratio. Reduction with LiAIH4 followed by methyl chloroformate/pyridine gave 32, which on treatment with MCPBA/CH2CL2/imidazole resulted in 33. Hydrolysis of 33 gave 34, which when exposed to KOBu(t)/HMPA at 90 °C resulted in 39. After conversion of 39 into enone 42, epoxidation with NaHCO3/H2O2/MeOH gave 43. Reduction of 43 with L-selectride followed by solvolysis with sodium benzoate in water gave 46, which was immediately acetylated to give 47. Lactam formation (Tf2O/DMAP) converted 47 into 48 and the regioisomer 49 (7:1). The mixture of 48 and 49 demethylated to give 50 and the acetate protecting groups removed to give (+)pancratistatin 1.