38930-22-2

Basic information

• Product Name: methyl 2-(2,6-dimethylphenoxy)acetate
• Synonyms: methyl 2-(2,6-dimethylphenoxy)acetate
• CAS NO: 38930-22-2
• Molecular Weight: 194.23
• Mol File: 38930-22-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 2-(2,6-dimethylphenoxy)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(2,6-dimethylphenoxy)acetate(38930-22-2)
• EPA Substance Registry System: methyl 2-(2,6-dimethylphenoxy)acetate(38930-22-2)

Safety Data

• Hazardous Substances Data: 38930-22-2(Hazardous Substances Data)

Upstream product

• 576-26-1 2.6-dimethylphenol 
• 96-32-2 bromoacetic acid methyl ester 
• 533-58-4 2-Iodophenol 
• 186395-08-4 methyl 2-(2-iodophenoxy)acetate 
• 616-38-6 carbonic acid dimethyl ester 
• 96-34-4 methyl chloroacetate 

Downstream Products

• 115057-33-5 methyl 2,6-dimethyl-4-(4-methoxybenzoyl)phenoxyacetate 
• 35370-86-6 2-(2,6-Dimethyl-phenoxy)-thioacetamide 
• 13335-71-2 2-(2,6-dimethylphenoxy)acetic acid 
• 189357-33-3 KNI-727 
• 115057-36-8 (4-Carboxymethoxy-3,5-dimethylphenyl)-4-methoxyphenylcarbinol 
• 68839-81-6 methyl 4-acetyl-2,6-dimethylphenoxyacetate 
• 1572184-23-6 (E)-N’-((1H-indol-6-yl)methylene)-2-(2,6-dimethylphenoxy)acetohydrazide 
• 1572183-70-0 (E)-N’-((1H-indol-4-yl)methylene)-2-(2,6-dimethylphenoxy)acetohydrazide 
• 64106-78-1 2-(2,6-dimethylphenoxy)acetohydrazide 

Relevant articles and documents

Pd-Catalyzed ipso, meta-Dimethylation of ortho-Substituted Iodoarenes via a Base-Controlled C-H Activation Cascade with Dimethyl Carbonate as the Methyl Source

A methyl group can have a profound impact on the pharmacological properties of organic molecules. Hence, developing methylation methods and methylating reagents is essential in medicinal chemistry. We report a palladium-catalyzed dimethylation reaction of ortho-substituted iodoarenes using dimethyl carbonate as a methyl source. In the presence of K2CO3 as a base, iodoarenes are dimethylated at the ipso- and meta-positions of the iodo group, which represents a novel strategy for meta-C-H methylation. With KOAc as the base, subsequent oxidative C(sp3)-H/C(sp3)-H coupling occurs; in this case, the overall transformation achieves triple C-H activation to form three new C-C bonds. These reactions allow expedient access to 2,6-dimethylated phenols, 2,3-dihydrobenzofurans, and indanes, which are ubiquitous structural motifs and essential synthetic intermediates of biologically and pharmacologically active compounds.

Structure-activity relationship of small-sized HIV protease inhibitors containing allophenylnorstatine

We designed and synthesized a new class of peptidomimetic human immunodeficiency virus (HIV) protease inhibitors containing a unique unnatural amino acid, allophenylnorstatine [Apns; (2S,3S)-3-amino-2-hydroxy- 4-phenylbutyric acid], with a hydroxymethylcarbonyl (HMC) isostere as the active moiety. A systematic evaluation of structure - activity relationships for HIV protease inhibition, anti-HIV activities, and pharmacokinetic profiles has led to the delineation of a set of structural characteristics that appear to afford an orally available HIV protease inhibitor. Optimum structures, exemplified by 21f (JE-2147), incorporated 3-hydroxy-2- methylbenzoyl groups as the P2 ligand, (R)-5,5-dimethyl-1,3-thiazolidine-4- carbonyl (Dmt) residue at the P1' site, and 2-methylbenzylcarboxamide group as the P2' ligand. The present study demonstrated that JE-2147 has potent antiviral activities in vitro and exhibits good oral bioavailability and plasma pharmacokinetic profiles in two species of laboratory animals.