39220-86-5

Basic information

• Product Name: Benzenemethanol, 3,4-dimethoxy-a-(nitromethyl)-
• CAS NO: 39220-86-5
• Molecular Formula: C10H13NO5
• Molecular Weight: 227.217
• Mol File: 39220-86-5.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 3,4-dimethoxy-a-(nitromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 3,4-dimethoxy-a-(nitromethyl)-(39220-86-5)
• EPA Substance Registry System: Benzenemethanol, 3,4-dimethoxy-a-(nitromethyl)-(39220-86-5)

Safety Data

• Hazardous Substances Data: 39220-86-5(Hazardous Substances Data)

Usage

Properties

1. Chemical formula: C10H13NO5
2. Physical form: White to off-white crystalline powder
3. Functional groups: Nitro, alcohol, and methoxy groups attached to a benzene ring
4. Reactivity: Wide range of reactivity in organic chemistry
5. Usage: Synthesis of pharmaceuticals and organic compounds
6. Potential health hazards: Handle with care and follow safety precautions

Physical form

White to off-white crystalline powder

Functional groups

Nitro, alcohol, and methoxy groups attached to a benzene ring

Reactivity

Wide range of reactivity in organic chemistry

Usage

Synthesis of pharmaceuticals and organic compounds

Safety precautions

Handle with care due to potential health hazards

Upstream product

• 75-52-5 nitromethane 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 46729-91-3 1-(3,4-dimethoxyphenyl)-2-nitroethan-1-one 
• 2150-38-1 methyl 3,4-dimethoxybenzoate 
• 4876-02-2 N-(3,4-dimethoxyphenethyl)-phenyl acetamide 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 39628-26-7 N-(3,4-Dimethoxy-β-phenylaethyl)-acetoxyacetamid 
• 100619-46-3 N-(3,4-dimethoxyphenethyl)methoxyacetamide 
• 56997-75-2 N-(3,4-dimethoxyphenethyl)-α-bromoacetamide 
• 4876-00-0 1-benzyl-6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 4230-93-7 3,4-dimethoxynitrostyrene 
• 1391133-80-4 N-[2-(3,4-dimethoxyphenyl)-2-hydroxyethyl]-4-(1,3-dioxo-1,3-dihydro-2H-isoindolin-2-yl)butanamide 
• 6924-15-8 2-amino-1-(3,4-dimethoxy-phenyl)-ethanol 

Relevant articles and documents

Waste-to-useful: A biowaste-derived heterogeneous catalyst for a green and sustainable Henry reaction

Owing to the depletion of resources coupled with increasing waste generation, the conversion of waste biomass to value-added materials has gained interest. Here, we report for the first time the application of Musa acuminata (banana) peel ash (MAPA) as a heterogeneous catalyst for C-C bond formation via a Henry reaction under solvent-free conditions at ambient temperature. The catalyst was well characterized using different analytical techniques like FT-IR, SEM, TEM-EDS, XRD, XRF, XPS, BET and TGA, along with basicity determination by a Hammett indicator test and titration method. An excellent yield of nitroalcohol was obtained within 15-30 minutes. No dehydrated product was observed. The catalyst used in these studies has the advantage of being a waste material and is hence low-cost, easily prepared, recyclable and environmentally friendly. In addition, the use of a biogenic renewable catalyst, its atom economy, and room temperature and solvent-free reaction conditions and the avoidance of column chromatography make the protocol highly significant from green and sustainable chemistry perspectives.

Diaminosilane-functionalized on silicate-stabilised hydrotalcite (MA-HTSi-DA): As potential catalyst for nitro-aldol condensation

Diaminosilane was introduced into silicate-anion-intercalated hydrotalcite (HT-Si) using a post-synthesis method. The resulting functionalized materials possess surface basicity. The textural properties of the functionalized materials were systematically investigated through powder XRD, FTIR and MAS-NMR studies. The diamine-functionalized materials showed very good catalytic activity for the nitro-aldol condensation of benzaldehyde and nitromethane under solvent-free conditions. The materials showed comparable catalytic activity upon recycling.

Designing new analogs for streamlining the structure of cytotoxic lamellarin natural products

Despite the therapeutic potential of marine-derived lamellarin natural products, their preclinical development has been hampered by their lipophilic nature, causing very poor aqueous solubility. In order to develop more drug-like analogs, their structure was streamlined in this study from both the cytotoxic activity and lipophilicity standpoints. First, a modified total synthetic route was successfully devised to construct a library of 59 systematically designed lamellarin analogs, which were then subjected to cytotoxicity and log P determinations. Along with the 25 first-generation lamellarins previously synthesized in our laboratory, the structure-activity and structure-lipophilicity relationships were extensively evaluated. Our results clearly indicated the additional structural requirements around the lamellarin skeleton which, when combined with those reported previously, can provide invaluable guidance for further modifications to increase the aqueous solubility of these compounds.