56997-75-2

Basic information

• Product Name: N-(bromoacetyl)homoveratrylamine
• Synonyms: N-(bromoacetyl)homoveratrylamine
• CAS NO: 56997-75-2
• Molecular Formula: C₁₂H₁₆BrNO₃
• Molecular Weight: 302.18
• Mol File: 56997-75-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 448.4°Cat760mmHg
• Flash Point: 225°C
• Appearance: /
• Density: 1.358g/cm³
• Vapor Pressure: 3.11E-08mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: N-(bromoacetyl)homoveratrylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(bromoacetyl)homoveratrylamine(56997-75-2)
• EPA Substance Registry System: N-(bromoacetyl)homoveratrylamine(56997-75-2)

Safety Data

• Hazardous Substances Data: 56997-75-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H16BrNO3/c1-16-10-4-3-9(7-11(10)17-2)5-6-14-12(15)8-13/h3-4,7H,5-6,8H2,1-2H3,(H,14,15)

Upstream product

• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 598-21-0 2-Bromoacetyl bromide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 39220-86-5 2-nitro-1-(3,4-dimethoxyphenyl)ethanol 
• 22118-09-8 2-bromoacetyl chloride 
• 79-08-3 bromoacetic acid 

Downstream Products

• 826992-39-6 diethyl [2-(2-(3,4-dimethoxyphenyl)ethylamino)-2-oxoethyl]phosphonate 
• 39628-26-7 N-(3,4-Dimethoxy-β-phenylaethyl)-acetoxyacetamid 
• 1393643-46-3 N-hydroxy-4-{[(3,4-dimethoxyphenethylcarbamoylmethyl)amino]methyl}benzamide 
• 1255709-84-2 C₂₂H₃₁NO₈ 
• 1181785-30-7 C₂₂H₂₂N₂O₅ 

Relevant articles and documents

SAR and identification of 2-(quinolin-4-yloxy)acetamides as Mycobacterium tuberculosis cytochrome bc 1 inhibitors

A previous phenotypic screen by GSK identified 2-(quinolin-4-yloxy)acetamides as potent growth inhibitors of Mycobacterium tuberculosis (Mtb). We report the results of a preliminary structure-activity relationship (SAR) study of the compound class which has yielded more potent inhibitors. An Mtb cytochrome bd oxidase deletion mutant (cydKO) was found to be hypersensitive to most members of the compound library, while strains carrying single-nucleotide polymorphisms of the qcrB gene, which encodes a subunit of the menaquinol cytochrome c oxidoreductase (bc1) complex, were resistant to the library. These results identify that the 2-(quinolin-4-yloxy)acetamide class of Mtb growth inhibitors can be added to the growing number of scaffolds that target the M. tuberculosis bc1 complex.

Design, synthesis and biological evaluation of hydroxamic acid derivatives as potential high density lipoprotein (HDL) receptor CLA-1 up-regulating agents

Trichostatin A (TSA) and suberoylanilide hydroxamic acid (SAHA) were reported in our recent publication as novel human high density lipoprotein (HDL) receptor CD36 and Lysosomal integral membrane protein-II Analogous-1 (CLA-1) up-regulators. As part of a