39253-43-5

Basic information

• Product Name: N-(4-Methoxyphenyl)-4-methylbenzenamine
• Synonyms: (4-METHOXY-PHENYL)-P-TOLYL-AMINE;N-(4-Methoxyphenyl)-4-methylbenzenamine;4-Methoxy-4'-methyldiphenylamine;4-methoxy-N-4-tolylaniline;(4-Methoxy-phenyl)-p-tolylanMine;N-(4-Methoxyphenyl)-p-tolylamine;4-Methoxy-N-(p-tolyl)aniline;N-(4-Methoxyphenyl)-4-methylbenzemine
• CAS NO: 39253-43-5
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.27
• EINECS: 1533716-785-6
• Mol File: 39253-43-5.mol
• Article Data: 94

Chemical Properties

• Melting Point: 82.0 to 86.0 °C
• Boiling Point: 354.944 °C at 760 mmHg
• Flash Point: 143.714 °C
• Appearance: /
• Density: 1.09 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: N-(4-Methoxyphenyl)-4-methylbenzenamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Methoxyphenyl)-4-methylbenzenamine(39253-43-5)
• EPA Substance Registry System: N-(4-Methoxyphenyl)-4-methylbenzenamine(39253-43-5)

Safety Data

• Hazardous Substances Data: 39253-43-5(Hazardous Substances Data)

Usage

General Description

N-(4-Methoxyphenyl)-4-methylbenzenamine is an organic compound, more specifically an aromatic amine. It is composed of a methoxyphenyl group (C6H5OCH3) and a methylbenzenamine group (C6H5NH2), both of which are bound to a central nitrogen atom. It is used primarily in the field of organic synthesis, where it can act as a building block for the production of more complex chemical structures. The compound's properties, like solubility, melting point, and boiling point, are generally defined by the nature of its aromatic rings and the presence of the amine and ether functional groups. Its exact properties and applications can vary greatly depending on the specific structure and configuration of the compound. Safety procedures should always be followed when handling it due to its potential toxicity.

InChI:InChI=1/C14H15NO/c1-11-3-5-12(6-4-11)15-13-7-9-14(16-2)10-8-13/h3-10,15H,1-2H3

Upstream product

• 624-31-7 4-tolyl iodide 
• 696-62-8 para-iodoanisole 
• 2101-86-2 p-methylazidobenzene 
• 100-66-3 methoxybenzene 
• 623-12-1 4-chloromethoxybenzene 
• 106-49-0 p-toluidine 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 66107-29-7 4-methoxyphenyl triflate 
• 384842-24-4 dicyclohexyl(1,1-diphenyl-1-propen-2-yl)phosphine 
• 106-38-7 para-bromotoluene 
• 104-94-9 4-methoxy-aniline 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 100-17-4 para-methoxynitrobenzene 
• 623-10-9 N-(4-methylphenyl)hydroxylamine 

Downstream Products

• 5234-30-0 glycozoline 
• 18440-54-5 N-(4-Methylphenyl)-1,4-benzoquinone monoimine 
• 59919-04-9 4-methoxy-N-methyl-N-(p-tolyl)aniline 
• 1378973-60-4 (E)-N-(1,3-diphenylallyl)-4-methoxy-N-p-tolylaniline 
• 1357929-84-0 C₈₁H₆₈N₄O₄ 
• 1357929-95-3 C₅₂H₇₂N₂O₆Si₆ 

Relevant articles and documents

Transition metals in organic synthesis, part 82.1 First total synthesis of methyl 6-methoxycarbazole-3-carboxylate, glycomaurrol, the anti-TB active micromeline, and the furo[2,3-c]carbazole alkaloid eustifoline-D

The palladium(0)-catalyzed animation followed by palladium(II)-catalyzed oxidative cyclization of the resulting diarylamine provides a short route to a series of 6-oxygenated carbazole alkaloids: glycozoline, 3-formyl-6- methoxycarbazole, methyl 6-methoxy

Electrochemical Reductive Arylation of Nitroarenes with Arylboronic Acids

The synthesis of diarylamine is extremely important in organic chemistry. Herein, a novel electrochemical reductive arylation of nitroarenes with arylboronic acids was developed. A variety of diarylamines were synthesized without the need for transition-metal catalysts. The reaction could be scaled up efficiently in a flow cell and several derivatization reactions were carried out smoothly. Cyclic voltammetry experiments and mechanism studies showed that acetonitrile, formic acid, and triethyl phosphite all played a role in promoting this reductive arylation transformation.

Cu(I)–N-heterocyclic carbene-catalyzed base free C–N bond formation of arylboronic acids with amines and azoles

A new N-heterocyclic carbene (NHC) precursor of imidazolium chloride and its corresponding Cu(I)–NHC complex 1 was synthesized. The complex 1 was found to be a highly effective catalyst for Chan-Evans-Lam coupling of arylboronic acid with amines and azoles (including imidazole, pyrazole and triazole), without addition of base at room temperature. Various substituents on three substrates can be tolerated, giving the desired coupling products in good to excellent yields (62–94%). The method is practical and offers an alternative to the corresponding copper-catalyzed Chan-Evans-Lam process for the construction of C–N bonds.