3969-09-3

Basic information

• Product Name: 5-Phenyl-2-methyloxazole
• Synonyms: 2-Methyl-5-phenyloxazole;5-Phenyl-2-methyloxazole;Nsc65666
• CAS NO: 3969-09-3
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.1846
• Mol File: 3969-09-3.mol
• Article Data: 45

Chemical Properties

• Boiling Point: 265.5°Cat760mmHg
• Flash Point: 104.6°C
• Appearance: /
• Density: 1.082g/cm³
• Vapor Pressure: 0.015mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: 5-Phenyl-2-methyloxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Phenyl-2-methyloxazole(3969-09-3)
• EPA Substance Registry System: 5-Phenyl-2-methyloxazole(3969-09-3)

Safety Data

• Hazardous Substances Data: 3969-09-3(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 54, p. 431, 1989 DOI: 10.1021/jo00263a033

InChI:InChI=1/C10H9NO/c1-8-11-7-10(12-8)9-5-3-2-4-6-9/h2-7H,1H3

Upstream product

• 93-91-4 1-phenylbutan-1,3-dione 
• 3282-32-4 2-diazo-acetophenone 
• 75-05-8 acetonitrile 
• 75-36-5 acetyl chloride 
• 7568-93-6 2-Amino-1-phenylethanol 
• 621-23-8 1,2,3-trimethoxybenzene 
• 98-86-2 acetophenone 
• 10026-13-8 phosphorus pentachloride 
• 1846-33-9 N-phenacylacetamide 
• 4053-38-7 8-methylquinoline 1-oxide 
• 536-74-3 phenylacetylene 
• 613-89-8 2-Aminoacetophenone 
• 302-72-7 rac-Ala-OH 
• 1722-84-5 (E)-N-styrylacetamide 

Downstream Products

• 952-33-0 4-(2-methyl-1,3-oxazol-5-yl)benzenesulfonamide 
• 1299491-10-3 (R)-2-methyl-5-phenyloxazoline 
• 14728-71-3 3,3'-diethyl-5,5'-diphenyl-2,2'-prop-1-ene-1,3-diyl-bis-oxazolium; diiodide 
• 293306-72-6 4-(2-methyl-oxazol-5-yl)-benzenesulfonyl chloride 
• 14224-96-5 ω-Acetamino-ω-methoxy-acetophenon 
• 117049-24-8 (1R,4S)-4-Methyl-1-phenyl-2,3,7-trioxa-5-aza-bicyclo[2.2.1]hept-5-ene 
• 64-19-7 acetic acid 
• 65-85-0 benzoic acid 
• 68395-80-2 2-tert-butyl-5-phenyl-1,3-oxazole 
• 74048-04-7 2-isopropyl-5-phenyloxazole 
• 128488-62-0 2-propyl-5-phenyloxazole 
• 128488-63-1 2-(3-pentyl)-5-phenyloxazole 
• 75220-92-7 1,4-bis<β-(5-phenyloxazol-2-yl)vinyl>benzene 
• 128488-65-3 2-(1,3-diphenyl-2-propyl)-5-phenyloxazole 

Relevant articles and documents

Formation of Oxazoles from Elusive Gold(I) α-Oxocarbenes: A Mechanistic Study

The gold(I) catalyzed reaction between phenylacetylene, pyridine N-oxide and acetonitrile leading, via a putative gold-α-oxocarbene intermediate, towards an oxazole product has been investigated. A novel mass spectrometric method called “delayed reactant

Water Can Accelerate Homogeneous Gold Catalysis

A selection of gold-catalyzed reactions was examined in a kinetic study on the influence of water on the rate constant. Two intramolecular reactions and one intermolecular reaction, which proceed via proton transfer and/or protodeauration steps, were inve

Homogeneous and Nanoparticle Gold-Catalyzed Hydrothiocyanation of Haloalkynes

The first homogeneous and heterogeneous nanoparticle gold-catalyzed addition of sulfur nucleophiles to alkynes was developed. More specifically, gold-catalyzed hydrothiocyanation of haloalkynes gave good yields and good stereoselectivity of vinyl thiocyanates. Furthermore, a sulfur-based gold catalyst (PPh3AuSCN) has shown a unique reactivity in gold-catalyzed reactions such as the cyclization of N-propargylic amides.

1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads

Two lead 1,3-oxazole-based carbonic anhydrase inhibitors (CAIs) earlier identified as selective, picomolar inhibitors of hCA II (a cytosolic target for treatment of glaucoma) have been investigated further. Firstly, they were found to be conveniently synt