3978-16-3 Usage
Description
2-[(Dimethylamino)methyl]indole, with the CAS number 3978-16-3, is a chemical compound that is characterized by its pale yellow oil appearance. It is primarily recognized for its utility in the field of organic synthesis, where it serves as a valuable building block for the creation of more complex molecules and compounds.
Uses
Used in Organic Synthesis:
2-[(Dimethylamino)methyl]indole is used as a synthetic building block for the development of various organic compounds. Its unique structure, which includes a dimethylamino group attached to a methylene bridge on an indole ring, allows for a wide range of chemical reactions and modifications, making it a versatile component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
In the Pharmaceutical Industry:
2-[(Dimethylamino)methyl]indole is used as a key intermediate in the synthesis of certain pharmaceutical compounds. Its incorporation into drug molecules can potentially enhance their biological activity, selectivity, and pharmacokinetic properties, leading to the development of more effective medications.
In the Agrochemical Industry:
2-[(Dimethylamino)methyl]indole is also utilized in the agrochemical sector, where it can be employed in the synthesis of novel pesticides, herbicides, and other crop protection agents. Its unique chemical properties may contribute to the development of more targeted and environmentally friendly agrochemicals.
In the Dye and Pigment Industry:
2-[(Dimethylamino)methyl]indole can be used as a starting material for the production of dyes and pigments, particularly those with specific color properties or applications in various industries, such as textiles, plastics, and printing inks.
In the Research and Development Sector:
Due to its unique chemical structure and reactivity, 2-[(Dimethylamino)methyl]indole is also valuable in academic and industrial research settings. It can be used as a model compound to study various chemical reactions, mechanisms, and the development of new synthetic methodologies.
Check Digit Verification of cas no
The CAS Registry Mumber 3978-16-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,9,7 and 8 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 3978-16:
(6*3)+(5*9)+(4*7)+(3*8)+(2*1)+(1*6)=123
123 % 10 = 3
So 3978-16-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H14N2/c1-13(2)8-10-7-9-5-3-4-6-11(9)12-10/h3-7,12H,8H2,1-2H3
3978-16-3Relevant articles and documents
Borinic Acid Catalysed Reduction of Tertiary Amides with Hydrosilanes: A Mild and Chemoselective Synthesis of Amines
Chardon, Aurélien,Mohy El Dine, Tharwat,Legay, Rémi,De Paolis, Micha?l,Rouden, Jacques,Blanchet, Jér?me
supporting information, p. 2005 - 2009 (2017/02/19)
A reduction of various aryl, alkyl, and α,β-unsaturated amides with phenylsilane, catalysed by a borinic acid, is reported. The unprecedented reaction was carried out under very mild conditions and led to useful amines. Furthermore, the reaction tolerates a variety of functional groups. Initial investigations implicated that an intermediate diarylhydroborane is involved in the reaction mechanism.
Palladium-catalyzed synthesis of 2-(aminomethyl)indoles from 3-(o -trifluoroacetamidoaryl)-1-propargylic alcohols and amines
Cacchi, Sandro,Fabrizi, Giancarlo,Goggiamani, Antonella,Molinaro, Carmela,Verdiglione, Rosanna
, p. 401 - 407 (2014/01/17)
A novel palladium-catalyzed approach to 2-(aminomethyl)indoles from 3-(o-trifluoroacetamidoaryl)-1-propargylic alcohols and amines has been developed.
Palladium-catalyzed synthesis of 2-(aminomethyl)indoles from ethyl 3-(o-trifluoroacetamidophenyl)-1-propargyl carbonate
Ambrogio, Ilaria,Cacchi, Sandro,Fabrizi, Giancarlo
, p. 2083 - 2086 (2007/10/03)
The palladium-catalyzed reaction of ethyl 3-(o-trifluoroacetamidophenyl)-1- propargyl carbonate with piperazines in the presence of Pd(PPh3) 4 in THF at 80 °C affords 2-(piperazin-1-ylmethyl)indoles in excellent yields. Good to excellent yields are also obtained with other secondary amines.
