889868-60-4

Basic information

• Product Name: ethyl 3-(o-trifluoroacetamidophenyl)-1-propargyl carbonate
• Synonyms: ethyl 3-(o-trifluoroacetamidophenyl)-1-propargyl carbonate
• CAS NO: 889868-60-4
• Molecular Weight: 315.249
• Mol File: 889868-60-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl 3-(o-trifluoroacetamidophenyl)-1-propargyl carbonate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(o-trifluoroacetamidophenyl)-1-propargyl carbonate(889868-60-4)
• EPA Substance Registry System: ethyl 3-(o-trifluoroacetamidophenyl)-1-propargyl carbonate(889868-60-4)

Safety Data

• Hazardous Substances Data: 889868-60-4(Hazardous Substances Data)

Upstream product

• 143321-89-5 2,2,2-trifluoro-N-(2-iodophenyl)acetamide 
• 287477-27-4 2-[3-(tetrahydro-2H-pyran-2-yloxy)prop-1-yn-1-yl]aniline 
• 201813-43-6 2,2,2-Trifluoro-N-{2-[3-(tetrahydro-pyran-2-yloxy)-prop-1-ynyl]-phenyl}-acetamide 
• 615-43-0 2-iodophenylamine 
• 541-41-3 chloroformic acid ethyl ester 
• 148564-88-9 2,2,2-trifluoro-N-(2-(3-hydroxyprop-1-ynyl)phenyl)acetamide 

Downstream Products

• 1186238-71-0 C₂₂H₂₅N₃O₂ 
• 1186238-74-3 C₁₆H₂₀N₂O 
• 1186238-69-6 C₂₀H₂₀FN₃O 
• 95-20-5 2-methyl-1H-indole 
• 66946-71-2 1-formyl-2-methyl-indole 
• 3978-16-3 N-((1H-indol-2-yl)methyl)-N-ethylethanamine 

Relevant articles and documents

Sequential alkylation/cyclization/isomerization of ethyl 3-(o-trifluoroacetamidoaryl)-1-propargylic esters: A new route to 2-acyl- and 2-ethoxycarbonyl-3-alkenyl indoles

The reaction of ethyl 3-(o-trifluoroacetamidoaryl)-1-propargylic esters with ethyl iodoacetate or α-bromoacetophenone in the presence of K 2CO3 in DMSO provides a new simple access to 2-acyl- and 2-ethoxycarbonyl-3-alkenyl indoles.

2-Alkylindoles via palladium-catalyzed reductive cyclization of ethyl 3-(o-trifluoroacetamidophenyl)-1-propargyl carbonates

The reaction of ethyl 3-(o-trifluoroacetamidophenyl)-1-propargyl carbonates with formate anions in the presence of Pd(PPh3)4 affords 2-alkylindoles in good to excellent yields.