39961-95-0Relevant articles and documents
Copolymerization of carbon dioxide and propylene oxide catalyzed by two kinds of bifunctional salen-cobalt(III) complexes bearing four quaternary ammonium salts
Du, Longchao,Wang, Chengze,Zhu, Weiju,Zhang, Jie
, p. 72 - 79 (2019/07/12)
Two new bifunctional salen-cobalt(III) complexes were synthesized, which consist of salicylaldehyde bearing four quaternary ammonium salts and two different diamines. The copolymerization results indicated that decreasing temperature is advantageous for both the complexes. Of both the diamines, the complex 9 with o-diaminobenzene has a higher catalytic effect compared to complex 6 with 1,2-diaminocyclohexane. The catalytic effect of complex 9 is over 3.5 times than that of complex 6 at a temperature of 30°C. The research of PCO2 on the copolymerization revealed that the first-rank pressure was at 2 MPa for the two complexes. The highest turnover number are under conditions of T = 30°C, PCO2 = 2 MPa, and t = 24 hr. Differential scanning calorimeter curves indicated that poly(propylene carbonate) (PPC) by complex 9 has the highest Tg of 54.2°C. DTGA curves showed that there were two thermal degradation peaks, the first is for the ester bond, and the second is for the C–C bond.
Spectroscopic exploration of binding of new imidazolium-based palladium(II) saldach complexes with CT-DNA as anticancer agents against HER2/neu overexpression
Alfaifi, Mohammad Y.,Elbehairi, Serag Eldin I.,Hafez, Hani S.,Elshaarawy, Reda F.M.
, p. 118 - 128 (2019/05/06)
The HER2/neu has shown a potential role in the choice of active chemotherapy for breast tumors because of its prognostic relevance and putative role in predicting drug resistance. Moreover, suppressing DNA replication has become an attractive strategy for treating cancer patients. In this attempt, the present study aimed to prepare new series of bis-imidazolium-based saldach {H2(Et)2saldach (nBu-Im+-X–)2} and their cis-Pd(II) complexes (saldach = N,N′-bis-(salicylidene)-R,R-1,2-diaminocyclohexane; X = Cl, PF6, BF4) as anticancer agents. The in vitro cytotoxicity activity of new cis-Pd(II) complexes against human breast adenocarcinoma cell lines (MCF-7) revealed higher growth-inhibitory effect than the native ligands. They induced a significant decrease for the protein HER2/neu expression with p 50 = 8.5 ± 0.2 μM) in inhibition of cell proliferation. Additionally, in vitro studies of Pd(II) complex (5a) using UV–Vis spectroscopy and binding affinity toward the calf thymus (CT) DNA) showed a combination of covalent, intercalation, hydrogen bonding interactions through formation of (CT-DNA).
Asymmetric Grignard Synthesis of Tertiary Alcohols through Rational Ligand Design
Bieszczad, Bartosz,Gilheany, Declan G.
supporting information, p. 4272 - 4276 (2017/04/03)
A simple, general and practical method is reported for highly enantioselective construction of tertiary alcohols through the direct addition of organomagnesium reagents to ketones. Discovered by rational ligand design based on a mechanistic hypothesis, it has an unprecedented broad scope. It utilizes a new type of chiral tridentate diamine/phenol ligand that is easily removed from the reaction mixture. It is exemplified by application to a formal asymmetric synthesis (>95:5 d.r.) of vitamin E.