400737-46-4

Basic information

• Product Name: (2R,3S,4S,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-3-trimethylsilanyloxy-octanoic acid methoxy-methyl-amide
• Synonyms: (2R,3S,4S,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-3-trimethylsilanyloxy-octanoic acid methoxy-methyl-amide
• CAS NO: 400737-46-4
• Molecular Weight: 599.956
• Mol File: 400737-46-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2R,3S,4S,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-3-trimethylsilanyloxy-octanoic acid methoxy-methyl-amide(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S,4S,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-3-trimethylsilanyloxy-octanoic acid methoxy-methyl-amide(400737-46-4)
• EPA Substance Registry System: (2R,3S,4S,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-3-trimethylsilanyloxy-octanoic acid methoxy-methyl-amide(400737-46-4)

Safety Data

• Hazardous Substances Data: 400737-46-4(Hazardous Substances Data)

Upstream product

• 51735-75-2 trimethylsilyl trifluoromethanesulfonate 
• 400737-43-1 (2R,3S,4R,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-octanoic acid methoxy-methyl-amide 
• 400737-23-7 2-[(R)-3-Methoxy-2-(4-methoxy-benzyloxy)-propyl]-[1,3]dithiane 
• 400737-30-6 (3R,4R,6R)-7-Methoxy-6-(4-methoxy-benzyloxy)-3-methyl-hept-1-en-4-ol 
• 400737-27-1 (R)-4-Methoxy-3-(4-methoxy-benzyloxy)-butyraldehyde 
• 400737-20-4 (R)-1-[1,3]Dithian-2-yl-3-methoxy-propan-2-ol 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 400737-40-8 (R)-4-Benzyl-3-[(2R,3S,4R,5R,7R)-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-octanoyl]-oxazolidin-2-one 
• 400737-33-9 tert-Butyl-{(1R,2R)-1-[(R)-3-methoxy-2-(4-methoxy-benzyloxy)-propyl]-2-methyl-but-3-enyloxy}-dimethyl-silane 
• 400737-36-2 (2S,3R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-methoxy-5-(4-methoxy-benzyloxy)-2-methyl-hexanal 

Downstream Products

• 647014-98-0 (E)-(2R,4R,5S,6S,7R,12S,13S)-4,6,13-Tris-(tert-butyl-dimethyl-silanyloxy)-1,12-dimethoxy-2-(4-methoxy-benzyloxy)-5,7-dimethyl-octadec-9-en-16-yn-8-one 
• 647014-99-1 (E)-(2R,4R,5R,6S,7R,12S,13S)-4,13-Bis-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-1,12-dimethoxy-2-(4-methoxy-benzyloxy)-5,7-dimethyl-octadec-9-en-16-yn-8-one 
• 647014-97-9 [(3R,4S,5S,6R,8R)-4,6-Bis-(tert-butyl-dimethyl-silanyloxy)-9-methoxy-8-(4-methoxy-benzyloxy)-3,5-dimethyl-2-oxo-nonyl]-phosphonic acid dimethyl ester 
• 647014-96-8 [(3R,4S,5R,6R,8R)-6-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-9-methoxy-8-(4-methoxy-benzyloxy)-3,5-dimethyl-2-oxo-nonyl]-phosphonic acid dimethyl ester 
• 400737-51-1 (2R,3S,4R,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-[1,3]dithian-2-yl-8-methoxy-7-(4-methoxy-benzyloxy)-4-methyl-octan-3-ol 
• 400736-37-0 2-[(1R,2S,3S,4R,6R)-2,4-Bis-(tert-butyl-dimethyl-silanyloxy)-7-methoxy-6-(4-methoxy-benzyloxy)-1,3-dimethyl-heptyl]-[1,3]dithiane 
• 400737-49-7 (2R,3S,4S,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-3-trimethylsilanyloxy-octanal 

Relevant articles and documents

Antitumor drugs and methods

Derivatives of apoptolidin, including skeletal homologues, are potent and selective apoptosis-inducing agents which, unlike apoptolidin, do not undergo isomerization under physiological conditions. These compounds exhibit antitumor properties, often superior to those of apoptolidin, and as such can be used in the treatment of cancer and other hyperproliferative disorders.

Total Synthesis of Apoptolidin: Completion of the Synthesis and Analogue Synthesis and Evaluation

The total synthesis of apoptolidin (1) is reported together with the design, synthesis, and biological evaluation of a number of analogues. The assembly of key fragments 6 and 7 to vinyl iodide 3 via dithiane coupling technology was supplemented by a seco