40119-34-4

Basic information

• Product Name: 2-Methyl-2-p-tolylpropanenitrile
• Synonyms: 2-Methyl-2-p-tolylpropanenitrile;Benzeneacetonitrile, α,α,4-triMethyl-
• CAS NO: 40119-34-4
• Molecular Formula: C₁₁H₁₃N
• Molecular Weight: 159.22762
• Mol File: 40119-34-4.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Methyl-2-p-tolylpropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-2-p-tolylpropanenitrile(40119-34-4)
• EPA Substance Registry System: 2-Methyl-2-p-tolylpropanenitrile(40119-34-4)

Safety Data

• Hazardous Substances Data: 40119-34-4(Hazardous Substances Data)

Usage

General Description

2-Methyl-2-p-tolylpropanenitrile, also known as P2-MN, is a colorless liquid used in the chemical industry for various processes, including in the production of pharmaceuticals, agrochemicals, and specialty chemicals. It is a nitrile compound that is primarily used as a precursor in the synthesis of other organic compounds. It is known for its high reactivity in organic synthesis and is commonly used as a building block in the preparation of complex molecules. Additionally, it is used as a stabilizer in the manufacturing of rubber and plastics. P2-MN is considered a hazardous material and requires proper handling and storage due to its toxic and flammable nature.

Upstream product

• 2947-61-7 (4-methylphenyl)acetonitrile 
• 74-88-4 methyl iodide 
• 1195-32-0 1-methyl-4-isopropenylbenzene 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 78-82-0 Isobutyronitrile 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 40919-17-3 α,α-Dimethyl-4-tolylacetylchlorid 
• 1201645-56-8 N-(5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridine-3-yl)benzenesulfonamide 
• 1201645-49-9 N-(3-(1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)phenyl)benzamide 
• 1201645-42-2 2-(4-(8-(9H-carbazol-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile 
• 1201644-55-4 tert-butyl 5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate 
• 1201645-15-9 2-(4-((6-(dibenzo[b,d]furan-3-yl)-3-nitroquinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile 
• 1286764-90-6 C₂₉H₂₂N₆O 
• 1201645-16-0 2-(4-((6-(dibenzo[b,d]furan-3-yl)-3-aminoquinolin-4-yl)methyl)phenyl)-2-methylpropanenitrile 
• 1201645-64-8 2-(4-(3-acetyl-8-(4-methylpiperazin-1-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile 
• 1201644-97-4 2-(4-(3-acetyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile 
• 1201645-73-9 2-methyl-2-(4-((6-(4-methylsulfonylpiperazin-1-yl)-3-nitroquinolin-4-yl)methyl)phenyl)propanenitrile 
• 1201645-34-2 N-(5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-2-yl)acetamide 
• 1201645-77-3 C₂₇H₃₁N₅O 
• 1201645-35-3 N-(5-(4-(4-(2-cyanopropan-2-yl)benzyl)-3-nitroquinolin-6-yl)pyridin-2-yl)acetamide 

Relevant articles and documents

Palladium-Catalyzed Distal m-C-H Functionalization of Arylacetic Acid Derivatives

Herein, we present m-C-H olefination on derivatives of phenylacetic acids by tethering with a simple nitrile-based template through palladium catalysis. Notably, the versatility of the method is evaluated with a wide range of phenylacetic acid derivatives for obtaining the meta-olefination products in fair to excellent yields with outstanding selectivities under mild conditions. Significantly, the present strategy is successfully exemplified for the synthesis of drugs/natural product analogues (naproxen, ibuprofen, paracetamol, and cholesterol).

Synthesis of Tertiary Benzylic Nitriles via Nickel-Catalyzed Markovnikov Hydrocyanation of α-Substituted Styrenes

The Markovnikov hydrocyanation of α-substituted styrenes enables the synthesis of tertiary benzylic nitriles under nickel catalysis. The Lewis-acid-free transformation features an unprecedented functional groups tolerance, including the-OH and-NH2 groups. A broad range of tertiary benzylic nitriles were obtained in good to excellent yields. In addition, an asymmetric version of this reaction was preliminarily investigated.

Synthesis and biologic activity of aryloxyaminopropanoles based on substituted p-tolylalkylamines

Reaction of 2,2-dimethyl-2-(p-tolyl)ethyl-, 1-p-tolylcyclopenthylmethyl- and 4-(p-tolyl)tetrahydro-2H-pyran-4-ylmethylamines with phenoxymethyloxiranes substituted in the aromatic ring afforded new aryloxypropanolamines, some of which show moderate adrenoblocking activity.