4020-99-9Relevant articles and documents
The unexpected formation of P-ylide in the reaction of 3-azido 1,4-benzodiazepine with tricyclohexylphosphine
Gololobov, Yu. G.,Krasnova, I. Yu.,Barabanov,Fedyanin,Andronati,Pavlovskii
, p. 233 - 236 (2015)
Reaction of substituted 3-azido 1,4-benzodiazepine with tricyclohexylphosphine is not the Staudinger reaction and unexpectedly results in P-ylide of 1,4-benzodiazepine. This is the first example of organic azides exhibiting the pseudo halide properties in the reactions of trivalent phosphorus compounds.
Silver-Catalyzed Regioselective Phosphorylation of para-Quinone Methides with P(III)-Nucleophiles
Liu, Yu,Tang, Ke-Wen,Wong, Wai-Yeung,Xie, Jun,Xiong, Biquan,Xu, Shipan,Xu, Weifeng
, p. 14983 - 15003 (2021/11/12)
A simple and efficient method for the silver-catalyzed regioselective phosphorylation of para-quinone methides (p-QMs) with P(III)-nucleophiles (P(OR)3, ArP(OR)2, Ar2P-OR) has been established via Michaelis-Arbuzov-type reaction. A broad range of P(III)-nucleophiles and para-quinone methides are well tolerated under the mild conditions, giving the expected diarylmethyl-substituted organophosphorus compounds with good to excellent yields. Moreover, a series of corresponding enantiomers can be obtained by employing dialkyl arylphosphonite (ArP(OR)2) as substrates. The control experiments and 31P NMR tracking experiments were also performed to gain insights for the plausible reaction mechanism. This protocol may have significant implications for the formation of C(sp3)-P bonds in Michaelis-Arbuzov-type reactions.
Synthesis method of diphenyl hypophosphite
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Paragraph 0041-0048, (2020/10/04)
The invention discloses a synthesis method of diphenyl hypophosphite, which belongs to the technical field of organic synthesis. The method comprises: by adopting N-methylimidazole as an acid-bindingagent, carrying out a reaction on diphenyl phosphorus chloride and an alcohol to obtain diphenyl hypophosphite and N-methylimidazole hydrochloride, carrying out standing and layering to remove the N-methylimidazole hydrochloride, and rectifying to obtain a finished product. The synthesis process does not need to add any solvent, is safe and environment-friendly, can remove the N-methylimidazole hydrochloride through layering, is simple to operate, mild in reaction condition, simple in wastewater and waste gas treatment, and easy to realize industrialization.