40281-50-3

Basic information

• Product Name: 3'-FLUORO-2-PHENYLACETOPHENONE
• Synonyms: 3'-FLUORO-2-PHENYLACETOPHENONE;1-(3-Fluorophenyl)-2-phenylethanone
• CAS NO: 40281-50-3
• Molecular Formula: C₁₄H₁₁FO
• Molecular Weight: 214.23
• Mol File: 40281-50-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 327.4°C at 760 mmHg
• Flash Point: 135.3°C
• Appearance: /
• Density: 1.152g/cm³
• Vapor Pressure: 0.000202mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: 3'-FLUORO-2-PHENYLACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-FLUORO-2-PHENYLACETOPHENONE(40281-50-3)
• EPA Substance Registry System: 3'-FLUORO-2-PHENYLACETOPHENONE(40281-50-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 40281-50-3(Hazardous Substances Data)

Usage

Description

3'-Fluoro-2-phenylacetophenone is a synthetic aromatic ketone with the chemical formula C14H11FO. This organic compound is characterized by the presence of a fluorine atom in the 3' position, which enhances its chemical reactivity and influences its physical properties. It is known for its diverse applications in the chemical and pharmaceutical industries.

Uses

Used in Organic Synthesis:
3'-Fluoro-2-phenylacetophenone is used as a building block in organic synthesis for creating more complex molecules. Its unique structure and reactivity make it a valuable component in the synthesis of various organic compounds.
Used in Pharmaceutical Industry:
3'-Fluoro-2-phenylacetophenone is used as a starting material in medicinal chemistry for the development of new pharmaceutical drugs. Its distinctive properties and interactions with other molecules make it a promising candidate for drug discovery and design.
Used in Chemical Research:
3'-Fluoro-2-phenylacetophenone has been studied for its chemical behavior and interactions with other molecules. Its unique properties make it an interesting subject for research in the field of chemistry, potentially leading to new insights and applications.

InChI:InChI=1/C14H11FO/c15-13-8-4-7-12(10-13)14(16)9-11-5-2-1-3-6-11/h1-8,10H,9H2

Upstream product

• 108-86-1 bromobenzene 
• 455-36-7 1-(3-fluorophenyl)ethanone 
• 1398057-04-9 1-(1-azidovinyl)-3-fluorobenzene 
• 100-63-0 phenylhydrazine 
• 1996-38-9 3-fluorobenzenediazonium tetrafluoroborate 
• 4747-15-3 1-(2-methoxyvinyl)benzene 
• 100-52-7 benzaldehyde 
• 455-68-5 methyl 3-fluorobenzoate 
• 108-88-3 toluene 
• 1711-07-5 3-fluorobenzoyl chloride 
• 456-48-4 3-Fluorobenzaldehyde 
• 100-39-0 benzyl bromide 
• 100948-28-5 2-(3-fluorophenyl)-2-((trimethylsilyl)oxy)acetonitrile 
• 768-35-4 3-fluorophenylboronic acid 

Downstream Products

• 185345-82-8 4-[2-(4-fluorophenyl)-2-oxoethyl]-1-benzenesulfonamide 
• 394-74-1 2-benzyl-3'-fluoro-benzophenone 
• 1283117-41-8 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-(3-fluorophenyl)-5-phenyl-3,4-dihydropyrimidi-2(1H)-one 
• 959407-69-3 1-(3-fluoro-phenyl)-2-phenyl-ethylamine 

Relevant articles and documents

H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water

An environmentally benign, cost-efficient and practical methodology for the room temperature synthesis of 2-arylacetophenones in water has been discovered. The facile and efficient transformation involves the oxidative radical addition of arylhydrazines with α-aryl vinyl azides in the presence of H2O2 (as a radical initiator) and PEG-800 (as a phase-transfer catalyst). From the viewpoint of green chemistry and organic synthesis, the present protocol is of great significance because of using cheap, non-toxic and readily available starting materials and reagents as well as amenability to gram-scale synthesis, which provides an attractive strategy to access 2-arylacetophenones.

Palladium-catalyzed synthesis of α-aryl acetophenones from styryl ethers and aryl diazonium saltsviaregioselective Heck arylation at room temperature

Preparation of α-aryl acetophenones from styryl ethers and aryldiazonium salts is described. The reaction is catalyzed by palladium acetate at room temperature in the absence of ligand and base. The developed method is highly attractive in terms of reaction conditions, substrate scope, functional group tolerance and yields. Synthetic applications of the present method are demonstrated by preparing α-aryl indoles and 3-aryl isocoumarin from styryl ethers.

Synthesis of unsymmetrical ketones by applying visible-light benzophenone/nickel dual catalysis for direct benzylic acylation

Herein, we report a dual catalytic system for the direct benzylic C-H acylation reaction furnishing a variety of unsymmetrical ketones. A benzophenone-derived photosensitizer combined with a nickel catalyst has been established as the catalytic system. Both acid chlorides and anhydrides are able to acylate the benzylic position of toluene and other methylbenzenes. The method offers a valuable alternative to late transition metal catalyzed C-H acylation reactions.