455-36-7

Basic information

• Product Name: 3'-Fluoroacetophenone
• Synonyms: Ethanone, 1-(3-fluorophenyl)-;3'-Fluoroacetophenone ,97%;3-fluorohypnone;Acetophenone, 3'-fluoro-;1-(3-FLUOROPHENYL)ETHAN-1-ONE;1-(3-FLUOROPHENYL)ETHANONE;3'-FLUOROACETOPHENONE;3-FLUOROACETOPHENONE
• CAS NO: 455-36-7
• Molecular Formula: C₈H₇FO
• Molecular Weight: 138.14
• EINECS: 207-245-4
• Product Categories: Benzene series;Fluorobenzene;ketone;Adehydes, Acetals & Ketones;Fluorine Compounds;C7 to C8;Carbonyl Compounds;Ketones;Acetophenone series;Aryl Fluorinated Building Blocks;Building Blocks;C7 to C8;C7-C8;Carbonyl Compounds;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Aromatic Acetophenones & Derivatives (substituted)
• Mol File: 455-36-7.mol
• Article Data: 50

Chemical Properties

• Melting Point: -3°C
• Boiling Point: 81 °C9 mm Hg(lit.)
• Flash Point: 177 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.126 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.27mmHg at 25°C
• Refractive Index: n20/D 1.509(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Slightly soluble in water.
• BRN: 907041
• CAS DataBase Reference: 3'-Fluoroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-Fluoroacetophenone(455-36-7)
• EPA Substance Registry System: 3'-Fluoroacetophenone(455-36-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-36/37/39-27
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 455-36-7(Hazardous Substances Data)

Usage

Chemical Properties

clear colourless to yellow liquid

Uses

3'-Fluoroacetophenone is used as raw material and intermediate in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs.

General Description

Bioreduction of 3′-fluoroacetophenone by cells of Aspergillus terreus in phosphate buffer solution-glycerol has been reported.

InChI:InChI=1/C8H7FO/c1-6(10)7-3-2-4-8(9)5-7/h2-5H,1H3

Upstream product

• 99-03-6 1-(3-aminophenyl)ethanone 
• 1711-07-5 3-fluorobenzoyl chloride 
• 98-86-2 acetophenone 
• 1121-86-4 1-Fluoro-3-iodobenzene 
• 75-36-5 acetyl chloride 
• 111-34-2 -butyl vinyl ether 
• 1073-06-9 3-fluorobromobenzene 
• 402-63-1 1-(3-fluorophenyl)ethanol 
• 1336-21-6 ammonium hydroxide 
• 2561-17-3 1-ethynyl-3-fluoro-benzene 
• 226260-01-1 3-fluoro-N-methoxy-N-methylbenzamide 
• 75-16-1 methylmagnesium bromide 
• 768-35-4 3-fluorophenylboronic acid 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 2378-25-8 (E)-1-(3-fluorophenyl)-3-phenylprop-2-en-1-one 
• 339-21-9 1-(3-fluoro-phenyl)-1-phenyl-ethanol 
• 52186-49-9 α-(Trimethylsiloxy)-m-fluorstyrol 
• 147218-00-6 N-<1-(3-fluorophenyl)ethylidene>-2-(trifluoromethyl)aniline 
• 139040-55-4 2-(3-Fluoro-phenyl)-2-hydroxy-N,N-dimethyl-thiopropionamide 
• 91842-71-6 1-(3-Fluoro-phenyl)-ethylidene-oxonium 
• 98-86-2 acetophenone 
• 455-38-9 3-fluorobenzoic acid 
• 175846-99-8 N-<1-(3-fluorophenyl)ethylidene>-2-(trifluoromethyl)aniline 
• 402-63-1 1-(3-fluorophenyl)ethanol 
• 23975-58-8 4,4,4-trifluoro-1-(3-fluorophenyl)butane-1,3-dione 
• 33166-77-7 ethyl 3-(3-fluorophenyl)-3-oxopropanoate 
• 200631-03-4 1-[3-fluoro-2-(2-(triethoxysilyl)ethyl)phenyl]ethanone 

Relevant articles and documents

Visible light-mediated, high-efficiency oxidation of benzyl to acetophenone catalyzed by fluorescein

An environmentally friendly aerobic oxidation of benzyl C(sp3)-H bonds to ketones via selective oxidation catalysis was developed. Fluorescein is an efficient photocatalyst with excellent chemical selectivity. The reaction has a wide substrate scope, and a successful gram-scale experiment demonstrated its potential industrial utility.

Photoinduced Acetylation of Anilines under Aqueous and Catalyst-Free Conditions

A green and efficient visible-light induced functionalization of anilines under mild conditions has been reported. Utilizing nontoxic, cost-effective, and water-soluble diacetyl as photosensitizer and acetylating reagent, and water as the solvent, a variety of anilines were converted into the corresponding aryl ketones, iodides, and bromides. With advantages of environmentally friendly conditions, simple operation, broad substrate scope, and functional group tolerance, this reaction represents a valuable method in organic synthesis.

Redox-driven deracemization of secondary alcohols by sequential ether/O2-mediated oxidation and Ru-catalyzed asymmetric reduction

The deracemization of benzylic alcohols has been achieved using a redox-driven one-pot two-step process. The racemic alcohols were oxidized by bis(methoxypropyl) ether and oxygen to give the ketone intermediates, followed by an asymmetric transfer hydrogenation with a chiral ruthenium catalyst. This compatible oxidation/reduction process gave the enantiomerically enriched alcohols with up to 95% ee values.