403-45-2Relevant articles and documents
Preparation method of 2-fluoro-5-formyl chloropyridine
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Page/Page column 4; 5, (2021/02/13)
The invention relates to a preparation method of 2-fluoro-5-formyl chloropyridine, and belongs to the technical field of organic chemistry. The method comprises the following steps: 1) taking 2-fluoro-5-methylpyridine as a raw material, and reacting in the presence of potassium permanganate or sodium permanganate to obtain 2-fluoro-5-formic acid pyridine; and 2) carrying out reflux reaction on the2-fluoro-5-formic acid pyridine and thionyl chloride or oxalyl chloride in a chlorinated solvent, after the reaction is finished, carrying out reduced pressure distillation on the solvent, adding analkane solvent, freezing, filtering to obtain a 2-fluoro-5-formyl chloropyridine solution, and carrying out reduced pressure distillation to obtain the 2-fluoro-5-formyl chloropyridine. According to the invention, the method has the advantages that the conversion rate is high, the purity of the obtained product reaches 99.0% or above, the single impurity content is smaller than 0.5%, the production cost is low, and the method is suitable for industrial production.
Nickel-catalyzed carboxylation of aryl iodides with lithium formate through catalytic CO recycling
Fu, Ming-Chen,Fu, Yao,Shang, Rui,Wu, Ya-Nan
supporting information, p. 4067 - 4069 (2020/04/20)
A protocol for the Ni-catalyzed carboxylation of aryl iodides with formate has been developed with good functional group compatibility for the synthesis of a variety of aromatic carboxylic acids under mild conditions. The reaction tolerates other functionalities for cross-coupling, such as aryl bromide, aryl chloride, aryl tosylate, and aryl pinacol boronate. The reaction proceeds through a carbonylation process with in situ generated carbon monoxide in the presence of a catalytic amount of acetic anhydride and lithium formate, avoiding the use of gaseous CO. The strategy of CO recycling in catalytic amounts is critical for the success of the reaction.
Rapid and efficient synthesis of [18F]fluoronicotinamides, [18F]fluoroisonicotinamides and [18F]fluorobenzamides as potential pet radiopharmaceuticals for melanoma imaging
Al Jammaz,Al-Otaibi,Okarvi,Amartey
scheme or table, p. 312 - 317 (2012/06/04)
In an attempt to simplify nucleophilic radiofluorination reactions to be amenable for automation, a series of [18F]fluoronicotinamides, [ 18F]fluoroisonicotinamides and [18F]fluorobenzamides were synthesized using one-step