40320-60-3Relevant articles and documents
A convenient method for the preparation of 3-azetidinylidene acetic acid
Vuilhorgne, Marc,Commercon, Alain,Mignani, Serge
, p. 605 - 606 (1999)
A facile route to novel 3-azetidinylidene acetic acid from commercially available epichlorohydrin is described.
Preparation method of tert-butyl-5-(hydroxymethyl)-7-oxa-2-azaspiro[3.5]nonane-2-formate
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Paragraph 0006; 0013, (2019/12/25)
The invention relates to a preparation method of tert-butyl-5-(hydroxymethyl)-7-oxa-2-azaspiro[3.5]nonane-2-formate, and mainly solves the technical problem that no proper industrial synthesis methodexists at present. The product is synthesized by six steps, and the preparation method comprises the steps: a first step, a compound 1 is subjected to Swern oxidation reaction to generate a compound 2; a second step, a compound 3 is obtained through a Horner-Wadsworth-Emmons reaction; a third step, a compound 4 is obtained through Michael addition; a fourth step, a compound 5 is obtained through reduction of the compound 4 with lithium tetrahydroaluminum; a fifth step, the compound 5 is dehydrated and retained with a ring to obtain a compound 6 under the action of sodium hydrogen; and a sixthstep, hydrogenation is preformed to remove a protective group, and then a protective group is added to obtain the target compound 7. The obtained compound is a useful intermediate or product for synthesis of many drugs.
1-diphenylmethylazetidine-3-ketone synthesis process method
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Paragraph 0013; 0014-0015, (2017/07/22)
The invention discloses a 1-diphenylmethylazetidine-3-ketone synthesis process method, which comprises: using 1-diphenylmethyl-3-hydroxy azetidine as a raw material, dissolving in DMSO, adding triethylamine, cooling to a temperature of 0-10 DEGC, adding pyridine sulfur trioxide in batches, carrying out a stirring reaction for 2 h at a room temperature, detecting the reaction through TLC until the reaction is completely performed, slowly adding ice water, completely stirring, adding ethyl acetate, extracting three times, combining the three collected organic phases, washing three times with 1/3 volume of saturated edible salt water, drying with anhydrous sodium sulfate, filtering, carrying out pressure reducing organic solvent removing on the filtrate to obtain a residual oil-like material, adding petroleum ether having the volume 5 times the volume of the residual oil-like material, beating, precipitating a yellow solid, filtering, and collecting the solid to obtain the 1-diphenylmethylazetidine-3-ketone. According to the present invention, compared to the traditional swern oxidation, the method of the present invention has advantages of simple operation and less feeding variety; compared to the final product purification methods in the similar literatures in the prior art, the method of the present invention is simple and is suitable for enlargement production; and the process method has advantages of low solvent consumption, emission reducing, and cost saving.