40438-48-0

Basic information

• Product Name: 2-(METHYLDIPHENYLSILYL)ETHANOL
• Synonyms: 2-(METHYLDIPHENYLSILYL)ETHANOL;(2-HYDROXYETHYL)DIPHENYMETHYLSILANE;2-(DIPHENYLMETHYLSILYL)ETHANOL;2-(methyldiphenylsilyl)-ethano;(2-hydroxyethyl)diphenylmethylsilane;Ethanol,2-(methyldiphenylsilyl)-;(2-Hydroxyethyl)diphenylmethylsilane, 2-(Diphenylmethylsilyl)ethanol
• CAS NO: 40438-48-0
• Molecular Formula: C₁₅H₁₈OSi
• Molecular Weight: 242.39
• EINECS: 254-919-9
• Mol File: 40438-48-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 152 °C0.2 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.063 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.49E-06mmHg at 25°C
• Refractive Index: n20/D 1.580(lit.)
• BRN: 4428743
• CAS DataBase Reference: 2-(METHYLDIPHENYLSILYL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(METHYLDIPHENYLSILYL)ETHANOL(40438-48-0)
• EPA Substance Registry System: 2-(METHYLDIPHENYLSILYL)ETHANOL(40438-48-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 23-24/25
• WGK Germany: 3
• Hazardous Substances Data: 40438-48-0(Hazardous Substances Data)

Usage

Uses

2-(Methyldiphenylsilyl)ethanol (2-(Diphenylmethylsilyl)ethanol) may be used in the preparation of 2-diphenylmethylsilylethyldithiophosphorodichloridate.

InChI:InChI=1/C15H18OSi/c1-17(13-12-16,14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-11,16H,12-13H2,1H3

Upstream product

• 144-79-6 chloromethyldiphenylsilane 
• 77772-21-5 tert-butyl α-(methyldiphenylsilyl)acetate 

Downstream Products

• 73364-60-0 Dithiophosphoric acid S,S'-bis-(4-methoxy-phenyl) ester O-[2-(methyl-diphenyl-silanyl)-ethyl] ester 
• 40438-47-9 diethyl 2-(diphenyl methylsilyl)-ethyl phosphate 
• 158817-18-6 bis<2-(methyldiphenylsilyl)ethyl> N,N-diisopropylphosphoramidite 
• 155398-45-1 (2-diphenylmethylsilylethoxy)bis(N,N-diisopropylamino)phosphine 
• 158852-07-4 5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-diphenylmethylsilylethyl N,N-diisopropyl phosphoramidite) 
• 79284-75-6 2-diphenylmethylsilylethyl S-p-methoxyphenyl 5'-O-monomethoxytritylthymidine 3'-phosphorothioate 
• 73364-59-7 2-diphenylmethylsilylethyl S-p-methoxyphenyl phosphorothioate 
• 79284-77-8 Thiophosphoric acid O-[(2S,3R,5S)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S-(4-methoxy-phenyl) ester O'-[2-(methyl-diphenyl-silanyl)-ethyl] ester 
• 158817-11-9 N^α-(9-fluorenylmethyloxycarbonyl)-O-phosphono>tyrosine 
• 158817-12-0 N^α-(benzyloxycarbonyl)-O-phosphono>tyrosine benzyl ester 
• 182966-92-3 C₅₈H₆₃N₄O₁₄PSSi 
• 160946-75-8 C₃₇H₄₅N₄O₁₂PSSi 

Relevant articles and documents

Synthesis and Application of Bis-Silylethyl-Derived Phosphate-Protected Fmoc-Phosphotyrosine Derivatives for Peptide Synthesis

Three Fmoc-phosphotyrosine derivatives with silylethyl-based phosphate protection were synthesized and evaluated for use in peptide synthesis.The stability of these derivatives toward piperidine/DMF (1:4) treatment and their cleavability with TFA solutions were examined.On the basis of these data, the bis-protected Fmoc-phosphotyrosine derivative or Fmoc-Tyr(PO3MDPSE2)-OH, was shown to be the most suitable candidate for the production of phosphotyrosine peptides.The syntheses of phosphotyrosine peptides including one containing Met and Cys are described.