4046-03-1Relevant articles and documents
A Convenient Method for Synthesis of Novel 3-(1,3,4-Oxadiazol-2-yl)-methylene-2-oxo-1,2,3,4-tetrahydroquinoxalines: Regioselective Cyclization of 3-Ethoxyhydrazonocarbonylmethylene-2-oxo-1,2,3,4-tetrahydroquinoxaline
Kurasawa, Yoshihisa,Moritaki, Yujiro,Takada, Atsushi
, p. 238 - 240 (1983)
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Synthesis and spectral luminescence properties of 2-aryl-5-methyl-1,3,4-oxadiazoles and zinc(ii) 2-(2-hydroxyphenyl)-5-methyl-1,3,4-oxadiazole complex
Artyushkina, Yu. M.,Dushenko, G. A.,Mikhailov, I. E.,Minkina, V. I.
, p. 176 - 178 (2020/04/17)
2-Aryl-5-methyl-1,3,4-oxadiazoles were synthesized by reflux of equimolar amounts of acyl hydrazides with triethyl orthoacetate in o-xylene. The obtained oxadiazoles, except for 2-(2-hydroxyphenyl)-5-methyl-1,3,4-oxadiazole, luminesce with a high quantum
Electrochemical Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles from α-Keto Acids and Acylhydrazines Under Mild Conditions
Lu, Fangling,Gong, Fengping,Li, Liangsen,Zhang, Kan,Li, Zhen,Zhang, Xinwei,Yin, Ying,Wang, Ying,Gao, Ziwei,Zhang, Heng,Lei, Aiwen
supporting information, p. 3257 - 3260 (2020/05/25)
1,3,4-Oxadiazoles are a kind of useful heterocycles which can be frequently found in materials and bioactive molecules. In this study, intermolecular electrochemical cyclization between α-keto acids and acylhydrazines has been developed for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles with the yield up to 91 %. This transformation can be run under mild reaction conditions in the absence of external oxidant, base and transition metal catalyst. Both symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles could be prepared according to the careful choice of the substrate combination. Gram scale synthesis also illustrates the potential application of this protocol in large preparation.