4048-33-3Relevant articles and documents
Sequential hydroaminomethylation/Pd-catalyzed hydrogenolysis as an atom efficient route to valuable primary and secondary amines
October, Jacquin,Mapolie, Selwyn F.
supporting information, (2021/04/12)
The facile synthesis of valuable primary and secondary amines is reported using a sequential procedure of hydroaminomethylation and Pd-catalyzed hydrogenolysis. The hydroaminomethylation reaction was catalyzed by a cationic Rh(I) iminopyridyl complex and the N-alkylated benzylamines were produced with high chemoselectivity, albeit as mixtures of linear and branched products. Performing the hydrogenolysis reaction using 10% Pd/C, provided access to valuable primary and secondary amines which have applications in the surfactant, pharmaceutical and polymer industries.
Synthesis method of 6-amino-1-hexanol
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Paragraph 0021-0056, (2020/09/30)
The invention relates to a synthesis method of 6-amino-1-hexanol. The synthesis method comprises the following steps: adding toluene and caprolactam into a reaction vessel, stirring, adding alkali into the reaction vessel in the stirring process, cooling the reaction temperature to the room temperature to obtain a primary reaction solution; slowly dropwise adding a red aluminum solution into the primary reaction solution, heating to carry out a reaction after dropwise adding so as to obtain a secondary reaction solution; cooling the secondary reaction solution, dropwise adding a quenching solution, continuously stirring for 15 minutes after dropwise adding, adding diatomite into the reaction vessel, stirring, filtering, carrying out reduced pressure distillation on the filtrate, and collecting fractions, thereby obtaining 6-amino-1-hexanol. The method has the advantages that the 6-amino-1-hexanol is synthesized from caprolactam by using red aluminum as a reducing agent, compared with existing rhodium and silver catalysts, the catalyst has the characteristics of short reaction time, mild conditions, low cost, simple process and the like, the maximal yield can reach 87%, and large-scale production is easy to realize.
Synthetic method 6-amino-1-hexanol
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Paragraph 0025; 0027; 0037; 0039, (2019/10/23)
The invention discloses a synthetic method 6-amino-1-hexanol. According to the synthetic method 6-amino-1-hexanol, chlorosulphonyl isocyanate and 1, 6-hexanediol are taken as main raw materials, one-pot method is adopted to synthesize 6-amino-1-hexanol. The synthesis route comprises following steps: 1, under the catalyst effect of a tertiary amine, chlorosulphonyl isocyanate and a primary alcoholare reacted to generate a Burgess reagent, 1, 6-hexanediol is added to generate an intermediate 6-hydroxyhexyl carbamic acid; and 2, the intermediate 6-hydroxyhexyl carbamic acid synthesized in step is subjected to projecting group removing directly without separation so as to obtain target product 6-amino-1-hexanol. The synthetic method is low in cost, simple in reaction conditions, few in reaction steps, short in time, and high in purity and yield of finished product 6-amino-1-hexanol.