40594-09-0

Basic information

• Product Name: Flucindole
• Synonyms: Flucindole;3-(Dimethylamino)-6,8-difluoro-1,2,3,4-tetrahydro-9H-carbazole;Win-35150
• CAS NO: 40594-09-0
• Molecular Formula: C₁₄H₁₆F₂N₂
• Molecular Weight: 250.29
• Mol File: 40594-09-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 365.1 °C at 760 mmHg
• Flash Point: 174.6 °C
• Appearance: /
• Density: 1.25
• Vapor Pressure: 1.61E-05mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: Flucindole(CAS DataBase Reference)
• NIST Chemistry Reference: Flucindole(40594-09-0)
• EPA Substance Registry System: Flucindole(40594-09-0)

Safety Data

• Hazardous Substances Data: 40594-09-0(Hazardous Substances Data)

Usage

Uses

Antipsychotic.

InChI:InChI=1/C14H16F2N2/c1-18(2)9-3-4-13-10(7-9)11-5-8(15)6-12(16)14(11)17-13/h5-6,9,17H,3-4,7H2,1-2H3

Upstream product

• 40594-30-7 2,4-difluorophenylhydrazine 
• 176661-76-0 (1,4-dioxa-spiro[4.5]dec-8-yl)dimethylamine 
• 40594-29-4 (2,4-difluorophenyl)hydrazinium chloride 

Relevant articles and documents

N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT6 receptor antagonists

The design, synthesis and SAR of novel tetrahydrocarbazole derivatives having 5-HT6 receptor antagonist activity is presented. The racemic compound 15e was found to possess desirable pharmacokinetic properties, adequate brain penetration and activity in animal models of cognition.

3-Amido-1,2,3,4-tetrahydrocarbazoles

3-(Substituted-amino)-1,2,3,4-tetrahydrocarbazoles are prepared by reacting appropriate 4-substituted-aminocyclohexanones with a phenylhydrazine, by reacting a 3-(sulfonyloxy)-1,2,3,4-tetrahydrocarbazole with an appropriate substituted amine, or by reduction of an appropriate 3-(acylamino)-1,2,3,4-tetrahydrocarbazole. The 3-(substituted-amino)-1,2,3,4-tetrahydrocarbazoles of this invention have analgetic and psychotropic activities. Moreover, certain of these compounds also have antihistaminic activity.