40594-30-7

Basic information

• Product Name: 2,4-Difluorophenylhydrazine
• Synonyms: Hydrazine,(2,4-difluorophenyl)-;TIMTEC-BB SBB003743;2,4-DIFLUOROPHENYL HYDRAZINE HCL;2,4-DIFLUOROPHENYLHYDRAZINE;2,4-DIFLUOROHYDRAZINOBENZENE HYDROCHLORIDE;1-(2,4-Difluorophenyl)hydrazine;BIO-FARMA BF000363;2,4-Difluorophenylhydrazine 95%
• CAS NO: 40594-30-7
• Molecular Formula: C₆H₆F₂N₂
• Molecular Weight: 144.12
• Mol File: 40594-30-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 65 °C
• Boiling Point: 185.1 °C at 760 mmHg
• Flash Point: 65.7 °C
• Appearance: /
• Density: 1.379 g/cm³
• Vapor Pressure: 0.71mmHg at 25°C
• PKA: 4.77±0.27(Predicted)
• CAS DataBase Reference: 2,4-Difluorophenylhydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Difluorophenylhydrazine(40594-30-7)
• EPA Substance Registry System: 2,4-Difluorophenylhydrazine(40594-30-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 40594-30-7(Hazardous Substances Data)

Usage

Uses

(2,4-difluorophenyl)hydrazine is a reactant in the preparation of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists.

InChI:InChI=1/C6H6F2N2.ClH/c7-4-1-2-6(10-9)5(8)3-4;/h1-3,10H,9H2;1H

Upstream product

• 367-25-9 2,4-difluorophenylamine 
• 40594-29-4 (2,4-difluorophenyl)hydrazinium chloride 

Downstream Products

• 143035-16-9 3-{1-[(2,4-Difluoro-phenyl)-hydrazono]-ethyl}-4-hydroxy-6-methyl-pyran-2-one 
• 220000-42-0 2-Benzoylamino-3-[(2,4-difluoro-phenyl)-hydrazono]-propionic acid ethyl ester 
• 442520-01-6 1-(2,4-difluoro-phenylamino)-pyrrole-2,5-dione 
• 37847-52-2 2,4-difluorobiphenyl 
• 928053-26-3 (4S,7R)-2-(2,4-difluoro-phenyl)-7,8,8-trimethyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one 
• 247565-75-9 ethyl 2-(2-(2,4-difluorophenyl)hydrazono)propanoate 
• 102996-25-8 5-amino-1-(2,4-difluorophenyl)-1H-pyrazole-4-carbonitrile 
• 562099-15-4 1-(2,4-difluorophenyl)-1H-pyrazole 
• 1134705-53-5 1-(2,4-difluorophenyl)-1H-pyrazole-4-carbaldehyde 
• 1375279-16-5 5-chloro-1H-indole-3-carboxaldehyde (2,4-difluorophenyl)hydrazone 
• 1451076-36-0 5-allyl-7,7-difluoro-2-(2,4-difluorophenyl)-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-amine 

Relevant articles and documents

Synthesis, insecticidal activities, and structure-activity relationship of phenylpyrazole derivatives containing a fluoro-substituted benzene moiety

Fluorinated organic compounds represent a growing and important family of commercial chemicals. Introduction of fluorine into active ingredients has become an effective way to develop modern crop protection products. Given the particular properties of fluorine and high efficiency and selectivity of diamide insecticides, we designed and synthesized 27 anthranilic diamides analogues containing fluoro-sustituted phenylpyrazole. A preliminary bioassay indicated that most target compounds exhibited good biological activity against Mythimna separata and Plutella xylostella. Compound IIIf containing a 2,4,6-trifluoro-substituted benzene ring showed 43% insecticidal activity against M. separata at 0.1 mg L-1, while the control chlorantraniliprole was 36%. The activity of IIIe against P. xylostella at 10-5 mg L-1 was 94%, compared with that of the control being 70%. Thus, introduction of fluorine into diamide insecticides was useful for increasing activity. Insect electrophysiology studies showed that the calcium concentration in the nerve cells of third M. separata larvae was elevated by IIIf, which further confirmed that ryanodine receptor (RyR) was its potential target.

Pyrazolones as inhibitors of 11B-hydroxysteroid dehydrogenase

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.