40780-62-9Relevant articles and documents
Enantioselective catalytic α-alkylation of aldehydes via an S N1 pathway
Brown, Adam R.,Kuo, Wen-Hsin,Jacobsen, Eric N.
supporting information; experimental part, p. 9286 - 9288 (2010/11/03)
Primary aminothiourea derivatives are shown to catalyze enantioselective alkylation of α-arylpriopionaldehdyes with diarylbromomethane. Evidence for a stepwise, S N1 mechanism in the substitution reaction induced by anion binding to the catalyst is provided by catalyst structure-activity studies, kinetic isotope effects, linear free-energy relationship studies, and competition experiments.