17498-07-6

Basic information

• Product Name: 1-deuteriodiphenylmethanol
• Synonyms: 1-deuteriodiphenylmethanol
• CAS NO: 17498-07-6
• Molecular Weight: 185.23
• Mol File: 17498-07-6.mol
• Article Data: 37

Chemical Properties

• CAS DataBase Reference: 1-deuteriodiphenylmethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-deuteriodiphenylmethanol(17498-07-6)
• EPA Substance Registry System: 1-deuteriodiphenylmethanol(17498-07-6)

Safety Data

• Hazardous Substances Data: 17498-07-6(Hazardous Substances Data)

Upstream product

• 119-61-9 benzophenone 
• 1693-74-9 tetrahydrofuran-d8 
• 109-99-9 tetrahydrofuran 
• 91-01-0 1,1-Diphenylmethanol 
• 3592-47-0 Benzaldehyde-d 
• 501-65-5 diphenyl acetylene 
• 26138-28-3 phenylytterbium iodide 
• 94-41-7 benzalacetophenone 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 
• 14629-59-5 diphenylmethyl trimethylsilyl ether 
• 20515-40-6 ammonium formate-d₁ 

Downstream Products

• 85316-19-4 α-deuterio-diphenylmethyl methyl ether 
• 1733-62-6 benzophenone 2,4-dinitrophenylhydrazone 
• 119-61-9 benzophenone 
• 4819-98-1 [4-²H]biphenyl 
• 40780-62-9 α-deuteriodiphenylmethylbromide 
• 112981-34-7 1-methyl-3-(1-deuteriodiphenylmethyloxycarbonyl)pyridinium iodide 
• 112981-47-2 1-methyl-4-(1-deuteriodiphenylmethyloxycarbonyl)pyridinium iodide 
• 85316-18-3 4,4-Diphenyl-<1,1,4-D3>butylbromid 
• 85316-24-1 4,4-Diphenyl-<1,1,4-D3>butanol 
• 85316-42-3 4,4-Diphenyl-<1,1,4-D3>butyllithium 
• 85316-23-0 4,4-Diphenyl-<4-D1>buttersaeure 
• 85316-22-9 3,3-Diphenyl-<3-D1>propylbromid 
• 85316-21-8 C₁₅H₁₅⁽²⁾HO 
• 78073-90-2 α-deutero-4-methoxytriphenylmethane 

Relevant articles and documents

The NiCl2·2H2O-Li-arene combination as reducing system. Part 3. Reduction of carbonyl compounds and imines

The reaction of different carbonyl compounds or their imines with a mixture of nickel(II) chloride dihydrate, an excess of lithium powder and a catalytic amount of naphthalene (16 mol %) or DTBB (8 mol %) in THF at room temperature, leads to the formation of the corresponding alcohols or amines, respectively. The incorporation of deuterium oxide into the nickel salt complex yields the corresponding deuterated products. The process can also be applied to α,β-unsaturated carbonyl compounds leading either to the hydrogenation of only the carbon-carbon double bond or the full hydrogenation, depending on the amount of the nickel salt and/or reaction times.

Extreme thermal stability of disodium 9-fluorenone dianion as a practical indicator for the preparation of absolute THF

The fact that the lifetime of the disodium 9-fluorenone dianion is longer than that of the corresponding benzophenone dianion in refluxing THF for more than several months, which was proved by their 1H NMR analyses and also by the isolated yields of their oxidation products (parent ketones), strongly suggests using 9-fluorenone as an excellent indicator for the preparation of absolute THF.

Light-driven MPV-type reduction of aryl ketones/aldehydes to alcohols with isopropanol under mild conditions

Alcohols are versatile structural motifs of pharmaceuticals, agrochemicals and fine chemicals. With respect to green chemistry, the development of more sustainable and cost-efficient processes for converting ketones/aldehydes to alcohols is highly desired. Herein, a direct light-driven strategy for reducing ketones/aldehydes to alcohols using isopropanol as the reducing agent and solvent, in the presence of t-BuOLi, under an air atmosphere at room temperature is developed. This operationally simple light-promoted Meerwein-Ponndorf-Verley (MPV) type reduction can be used to produce various benzylic alcohol derivatives as well as applied to bioactive molecules and PEEK model compounds, demonstrating its application potential.

Practical Method for Reductive Deuteration of Ketones with Magnesium and D2O

α-Deuterated alcohols have important applications in pharmaceuticals and mechanism studies. Here, we report a new and practical strategy for the reductive deuteration of ketones using a Mg/BrCH2CH2Br/D2O system, which affords α-deuterated alcohols in good yields and with almost quantitative incorporation of deuterium. The synthetic value of this method has been demonstrated by the easy access to deuterated drugs or drug derivatives. This method may inspire the discovery of other deuterium-containing drugs.