41024-58-2 Usage
Description
1-(4-FLUOROPHENYL)-2-(PHENYLSULFONYL)-1-ETHANONE is a chemical compound with the molecular formula C14H11FO3S. It is a ketone derivative that contains a fluorophenyl group and a phenylsulfonyl group. 1-(4-FLUOROPHENYL)-2-(PHENYLSULFONYL)-1-ETHANONE is commonly used in organic synthesis and pharmaceutical research, and it has potential applications in the development of new drugs and as a reagent in chemical reactions. The presence of the fluorophenyl and phenylsulfonyl groups gives this compound unique reactivity and properties, making it a valuable tool in the field of organic chemistry.
Uses
Used in Pharmaceutical Research:
1-(4-FLUOROPHENYL)-2-(PHENYLSULFONYL)-1-ETHANONE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique reactivity and properties allow for the development of new drugs with improved efficacy and reduced side effects.
Used in Organic Synthesis:
1-(4-FLUOROPHENYL)-2-(PHENYLSULFONYL)-1-ETHANONE is used as a reagent in various chemical reactions, facilitating the formation of complex organic molecules. Its fluorophenyl and phenylsulfonyl groups provide unique reaction pathways, enabling the synthesis of a wide range of organic compounds.
Used in Chemical Reactions:
1-(4-FLUOROPHENYL)-2-(PHENYLSULFONYL)-1-ETHANONE is used as a versatile building block in the construction of complex molecular structures. Its unique reactivity allows for the formation of various functional groups, making it an essential component in the synthesis of advanced materials and specialty chemicals.
Used in Drug Development:
1-(4-FLUOROPHENYL)-2-(PHENYLSULFONYL)-1-ETHANONE is used as a starting material in the development of new drugs. Its unique properties and reactivity make it an attractive candidate for the design and synthesis of novel therapeutic agents with improved pharmacological profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 41024-58-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,0,2 and 4 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 41024-58:
(7*4)+(6*1)+(5*0)+(4*2)+(3*4)+(2*5)+(1*8)=72
72 % 10 = 2
So 41024-58-2 is a valid CAS Registry Number.
41024-58-2Relevant articles and documents
Synthesis of β-Keto Sulfones by Oxy-Sulfonylation of Alkynes in HFIP
Chen, Xingyu,Lu, Sixian,Zheng, Yuyan,Wang, Jigang,Yang, Lan,Sun, Peng
, p. 1305 - 1312 (2022/03/14)
Herein, we have established a method for the construction of β-keto sulfones through aerobic oxy-sulfonylation of alkynes with sulfinates. The reaction performed employing air as the oxidant and oxygen source. Moreover, this protocol exhibits low consume of sulfinates, short reaction period, and minimal waste. Mechanism study and density functional theory (DFT) calculation showed that the solvent played a significant role in the transformation. (Figure presented.).
Oxidative Sulfonylation of Hydrazones Enabled by Synergistic Copper/Silver Catalysis
Xu, Jun,Shen, Chao,Qin, Xian,Wu, Jie,Zhang, Pengfei,Liu, Xiaogang
, p. 3706 - 3720 (2021/02/05)
A copper/silver-cocatalyzed protocol for oxidative sulfonylation of hydrazones is demonstrated. A wide range of β-ketosulfones and N-acylsulfonamides are directly synthesized in moderate to good yields. Our work provides a viable method for scalable preparation of β-ketosulfone derivatives that have found wide applications in the pharmaceutical industry.
A glucose oxidase-hemoglobin system for efficient oxysulfonylation of alkenes/alkynes in water
Li, Chen,Li, Fengxi,Li, Zhengqiang,Liu, Jiaxu,Su, Jiali,Wang, Chunyu,Wang, Lei,Xu, Yaning,Yu, Yue
, (2020/12/29)
Background: β-ketosulfones are important bioactive compounds that have been extensively studied in organic chemistry. In this work, a green and efficient process for the synthesis of β-ketosulfones from alkenes (1) or alkynes (3) with sodium benzenesulfinate (2) was developed. Results: Under optimal conditions (alkenes (0.5 mmol) or alkynes (0.5 mmol), sodium benzenesulfinate (0.5 mmol), water (2 mL), hemoproteins (heme concentration: 0.06 mol%), GOX (42 U/ml), room temperature, 2 h), high yields of β-ketosulfones could be obtained when HgbRb (hemoglobin from rabbit blood) and GOX (glucose oxidase from Aspergillus niger) was used as the catalyst. Conclusion: This enzymatic method demonstrates the great potential for the synthesis of β-ketosulfones and extends the application of dual protein systems in organic synthesis.
