41866-70-0

Basic information

• Product Name: 2,6-dimethyl-4-hydroxy-2,3,5,6-tetrahydro-4H-pyran
• Synonyms: 2,6-dimethyl-4-hydroxy-2,3,5,6-tetrahydro-4H-pyran
• CAS NO: 41866-70-0
• Molecular Weight: 130.187
• Mol File: 41866-70-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2,6-dimethyl-4-hydroxy-2,3,5,6-tetrahydro-4H-pyran(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dimethyl-4-hydroxy-2,3,5,6-tetrahydro-4H-pyran(41866-70-0)
• EPA Substance Registry System: 2,6-dimethyl-4-hydroxy-2,3,5,6-tetrahydro-4H-pyran(41866-70-0)

Safety Data

• Hazardous Substances Data: 41866-70-0(Hazardous Substances Data)

Upstream product

• 752244-29-4 (2R,6S)-2,6-dimethyltetrahydro-4H-pyran-4-one 
• 1004-36-0 2,6-dimethylpyrone 
• 64-17-5 ethanol 
• 111957-98-3 Pent-4-en-2-ol 
• 123-38-6 propionaldehyde 
• 100719-26-4 4-nitro-benzoic acid-(2r,6c-dimethyl-tetrahydro-pyran-4t-yl ester) 
• 33747-09-0 (2R,4S,6S)-2,6-dimethyltetrahydro-2H-pyran-4-ol 

Downstream Products

• 1306729-81-6 C₁₄H₂₀O₄S 
• 100719-26-4 4-nitro-benzoic acid-(2r,6c-dimethyl-tetrahydro-pyran-4t-yl ester) 
• 33747-09-0 2r,6c-Dimethyl-tetrahydro-pyran-4t-ol 
• 1306729-82-7 C₂₉H₃₁NO₃ 
• 1306729-83-8 C₁₈H₂₅NO₅ 
• 1306785-92-1 C₁₄H₂₀O₄S 
• 752244-29-4 (2R,6S)-2,6-dimethyltetrahydro-4H-pyran-4-one 
• 1620450-76-1 C₁₈H₂₃NO₅ 

Relevant articles and documents

Probing the mechanism of Prins cyclisations and application to the synthesis of 4-hydroxytetrahydropyrans

Trapping intermediates on the Prins cyclisation pathway with carbon-based nucleophiles has given further insight into factors affecting the acid-mediated reactions of homoallylic alcohols with aldehydes, enabling the design of efficient syntheses of 4-hyd

Discovery of MK-6169, a Potent Pan-Genotype Hepatitis C Virus NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Substitutions

We describe the discovery of MK-6169, a potent and pan-genotype hepatitis C virus NS5A inhibitor with optimized activity against common resistance-associated substitutions. SAR studies around the combination of changes to both the valine and aminal carbon region of elbasvir led to the discovery of a series of compounds with substantially improved potency against common resistance-associated substitutions in the major genotypes, as well as good pharmacokinetics in both rat and dog. Through further optimization of key leads from this effort, MK-6169 (21) was discovered as a preclinical candidate for further development.

HETEROCYCLE-SUBSTITUED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES

The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A', R 2 R 3, R 4 and R are as defined herein. The present i