418762-90-0

Basic information

• Product Name: 2-(1H-pyrrol-1-yl)benzenemethanamine hydrochloride salt
• Synonyms: 2-(1H-pyrrol-1-yl)benzenemethanamine hydrochloride salt
• CAS NO: 418762-90-0
• Molecular Weight: 243.136
• Mol File: 418762-90-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(1H-pyrrol-1-yl)benzenemethanamine hydrochloride salt(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-pyrrol-1-yl)benzenemethanamine hydrochloride salt(418762-90-0)
• EPA Substance Registry System: 2-(1H-pyrrol-1-yl)benzenemethanamine hydrochloride salt(418762-90-0)

Safety Data

• Hazardous Substances Data: 418762-90-0(Hazardous Substances Data)

Upstream product

• 418762-89-7 2-chloro-6-(1H-pyrrol-1-yl)benzonitrile 
• 6575-11-7 2-amino-6-chlorobenzonitrile 

Downstream Products

• 1352144-70-7 C₂₀H₁₇ClF₂N₂O 
• 1352144-35-4 7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride 
• 1352144-75-2 C₂₀H₁₆ClF₃N₂O 
• 1352144-55-8 7-chloro-4-[3-(1,1-difluoroethyl)-4-fluorophenyl]-6H-pyrrolo[1,2-a][1,4]benzodiazepine 
• 1352144-37-6 (4R)-7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride 
• 1352144-36-5 (4S)-7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]-benzodiazepine hydrochloride 
• 1352144-38-7 7-chloro-4-[4-(1,1-difluoroethyl)phenyl]-6H-pyrrolo[1,2-a][1,4]-benzodiazepine 
• 1383541-98-7 C₂₂H₂₁ClN₂O 
• 1383541-97-6 C₂₃H₂₂ClN₃O₂ 
• 1383542-02-6 C₂₁H₁₇ClF₂N₂O₂ 
• 1407994-21-1 C₂₀H₁₅ClN₂O₂ 
• 1407994-22-2 C₂₀H₁₅ClN₂OS 
• 1407994-20-0 C₁₈H₁₃ClF₃N₃O 

Relevant articles and documents

Driving Recursive Dehydration by PIII/PV Catalysis: Annulation of Amines and Carboxylic Acids by Sequential C-N and C-C Bond Formation

A method for the annulation of amines and carboxylic acids to form pharmaceutically relevant azaheterocycles via organophosphorus PIII/PV redox catalysis is reported. The method employs a phosphetane catalyst together with a mild bromenium oxidant and terminal hydrosilane reductant to drive successive C-N and C-C bond-forming dehydration events via the serial action of a catalytic bromophosphonium intermediate. These results demonstrate the capacity of PIII/PV redox catalysis to enable iterative redox-neutral transformations in complement to the common reductive driving force of the PIII/PV couple.

NOVEL ANTIFUNGAL 5,6-DIHYDRO-4-[(DIFLUOROETHYL)PHENYL]-4H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE AND 4-(DIFLUOROETHYL)PHENYL-6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINE DERIVATIVES

The present invention concerns novel compounds of Formula (I): wherein R1, R2, R3, R4, R5 and R6 have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]- BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH BICYCLIC BENZENE DERIVATIVES

The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo- [1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines substituted with bicyclic benzene derivatives of Formula (I) wherein R1, R2, Rsup