4202-14-6Relevant articles and documents
Organocatalytic enantioselective 1,3-dipolar cycloadditions between seyferth-gilbert reagent and isatylidene malononitriles: Synthesis of chiral spiro-phosphonylpyrazoline-oxindoles
Du, Taiping,Du, Fei,Ning, Yanqiang,Peng, Yungui
, p. 1308 - 1311 (2015)
A new method has been developed for the catalytic enantioselective 1,3-dipolar cycloaddition of the Seyferth-Gilbert reagent (SGR) to isatylidene malononitriles using a cinchona alkaloid derivative as a catalyst. This method allowed for the synthesis of a series of chiral spiro-phosphonylpyrazoline-oxindoles in good yields with excellent enantioselectivities. The synthetic utility of this method was further demonstrated by its use in a three-component domino reaction involving isatin, malononitrile, and SGR based on sequential Knoevenagel condensation and 1,3-dipolar cycloaddition reactions.
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Cotton,F.A.,Schunn,R.A.
, p. 2394 - 2402 (1963)
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Silver-Catalyzed Oxidative C(sp3)?P Bond Formation through C?C and P?H Bond Cleavage
Li, Lili,Huang, Wenbin,Chen, Lijin,Dong, Jiaxing,Ma, Xuebing,Peng, Yungui
supporting information, p. 10539 - 10544 (2017/08/22)
The silver-catalyzed oxidative C(sp3)?H/P?H cross-coupling of 1,3-dicarbonyl compounds with H-phosphonates, followed by a chemo- and regioselective C(sp3)?C(CO) bond-cleavage step, provided heavily functionalized β-ketophosphonates. This novel method based on a readily available reaction system exhibits wide scope, high functional-group tolerance, and exclusive selectivity.
A tunable copper-catalyzed multicomponent reaction towards alkaloid-inspired indole/lactam polycycles
Mardjan,Perie,Parrain,Commeiras
supporting information, p. 3304 - 3309 (2017/04/21)
A versatile copper(i)-catalyzed cascade multicomponent reaction strategy between readily available (Z)-3-iodoacrylic acids, terminal alkynes, and primary amines is reported, leading to a great diversity of complex heterocyclic backbones based on biorelevant indole/lactam scaffolds.