426-54-0

Basic information

• Product Name: 2-PHENYL-1,1,1-TRIFLUOROPROPAN-2-OL
• Synonyms: 2-PHENYL-1,1,1-TRIFLUOROPROPAN-2-OL;1,1,1-TRIFLUORO-2-PHENYL-PROPAN-2-OL;(R,S)-1,1,1-Trifluoro-2-phenyl-propan-2-ol;1-Methyl-1-phenyl-2,2,2-trifluoroethanol;2-Phenyl-1,1,1-trifluoropropan-2-ol,97%;2-Phenyl-1,1,1-trifluoropropan-2-ol 97%
• CAS NO: 426-54-0
• Molecular Formula: C₉H₉F₃O
• Molecular Weight: 190.16
• Product Categories: Aromatic Building Blocks
• Mol File: 426-54-0.mol
• Article Data: 36

Chemical Properties

• Boiling Point: 81-83/3mm
• Flash Point: 99.9 °C
• Appearance: /
• Density: 1.251
• Refractive Index: 1.4656
• PKA: 11.98±0.10(Predicted)
• CAS DataBase Reference: 2-PHENYL-1,1,1-TRIFLUOROPROPAN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-1,1,1-TRIFLUOROPROPAN-2-OL(426-54-0)
• EPA Substance Registry System: 2-PHENYL-1,1,1-TRIFLUOROPROPAN-2-OL(426-54-0)

Safety Data

• Hazard Codes: F
• Hazardous Substances Data: 426-54-0(Hazardous Substances Data)

Usage

General Description

2-Phenyl-1,1,1-trifluoropropan-2-ol is a chemical compound with the molecular formula C9H9F3O. It is a chiral molecule with a stereocenter at the second carbon atom. 2-Phenyl-1,1,1-trifluoropropan-2-ol is commonly used as a synthetic intermediate in the production of pharmaceuticals and agrochemicals. It possesses a phenyl group as well as a trifluoromethyl group, which gives it unique chemical properties that make it useful in organic synthesis. Its ability to serve as a chiral building block makes it valuable in the development of new chemical compounds for various applications. However, it should be handled with caution as it is a flammable liquid and can cause skin and eye irritation.

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Relevant articles and documents

Trifluoromethyl reagent as well as synthesis method and application thereof

The invention discloses a trifluoromethyl reagent as well as a synthesis method and application thereof, wherein the structural formula of the trifluoromethyl reagent is as shown in formula I in the specification. According to the invention, diphenyl trifluoromethylphosphine and iodomethane are used as raw materials, and are heated in an organic solvent to carry out an addition reaction to prepare the trifluoromethylation reagent. The method is simple and convenient in process, high in yield and capable of realizing 10-gram-level large-scale preparation; more importantly, the trifluoromethylation reagent can be used as a free radical and a nucleophilic reagent to be applied to free radical addition reaction and simple nucleophilic addition reaction to prepare different types of trifluoromethylation products, so that the method has important application value.

Synthesis of ethyl 5-aryl-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-carboxylates, exhibiting plant growth-regulating properties

A convenient method for the synthesis of high-boiling-point α-(trifluoromethyl)styrenes was proposed. The regioselective synthesis of a series of ethyl 5-aryl-5-(trifluoromethyl)-4,5- dihydroisoxazole-3-carboxylates was conducted by the reaction of ethyl

Organocatalysis approach to trifluoromethylation with fluoroform

The organic base methodology exploits an access to generate the "trifluoromethyl anion" for carbonyl, ester, acid halide, epoxide, deuterium donor, and carbon dioxide substrates to afford the trifluoromethylation products with good overall efficiency even in organocatalysis conditions. The NMR analysis of the mixture of fluoroform and P4-base shows no change thereof. However, on addition of electrophiles, the trifluoromethylation products were obtained efficiently.