426-58-4

Basic information

• Product Name: Phenyl (trifluoromethyl) sulfone
• Synonyms: (Trifluoromethyl) phenyl sulfone;Phenyl (trifluoromethyl) sulfone;Trifluoromethyl phenyl sulfone;(TrifluoroMethane)sulfonylbenzene;[(Trifluoromethyl)sulphonyl]benzene;Phenyl trifluoromethyl sulphone;((Trifluoromethyl)sulfonyl)benzene
• CAS NO: 426-58-4
• Molecular Formula: C₇H₅F₃O₂S
• Molecular Weight: 210.17
• Mol File: 426-58-4.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 203°C(lit.)
• Appearance: /
• Density: 1.423±0.06 g/cm3(Predicted)
• Refractive Index: 1.4620 to 1.4660
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: Phenyl (trifluoromethyl) sulfone(CAS DataBase Reference)
• NIST Chemistry Reference: Phenyl (trifluoromethyl) sulfone(426-58-4)
• EPA Substance Registry System: Phenyl (trifluoromethyl) sulfone(426-58-4)

Safety Data

• Hazardous Substances Data: 426-58-4(Hazardous Substances Data)

Usage

General Description

Phenyl (trifluoromethyl) sulfone, also known as trifluoromethyl phenyl sulfone or PhCF3SO2, is a chemical compound with the molecular formula C6H5SO2CF3. It is a sulfone derivative with a trifluoromethyl group attached to a phenyl ring. Phenyl (trifluoromethyl) sulfone is frequently used as a reagent in organic synthesis and can also be utilized as a precursor in the preparation of pharmaceuticals and agrochemicals. Phenyl (trifluoromethyl) sulfone is known for its high thermal stability and resistance to chemical reactions, making it valuable for a variety of applications in the chemical and pharmaceutical industries. Additionally, it has potential use as a prototype for developing new fluorinated compounds with unique properties.

Upstream product

• 368-43-4 phenylsulfonyl fluoride 
• 754-25-6 trimethyl(trifluoromethyl)tin 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 1193-82-4 racemic methyl phenyl sulfoxide 
• 456-56-4 phenyl trifluoromethylsulfide 
• 887144-94-7 Togni's reagent II 
• 873-55-2 sodium benzenesulfonate 
• 887144-97-0 Togni's reagent 
• 2926-29-6 Langlois reagent 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 17763-67-6 Phenyl triflate 
• 108-90-7 chlorobenzene 
• 108-86-1 bromobenzene 
• 369-57-3 benzenediazonium tetrafluoroborate 

Downstream Products

• 599-70-2 ethyl phenyl sulfone 
• 6947-57-5 cyclohexyl phenyl sulfone 
• 3112-85-4 methylphenylsulfonate 
• 4238-09-9 phenyl isopropyl sulfone 
• 34009-05-7 (octane-1-sulfonyl)-benzene 
• 127-63-9 diphenyl sulphone 
• 640-57-3 phenyltolylsulfone 
• 16212-05-8 (allylsulfonyl)benzene 
• 2358-41-0 1-fluoro-2-[(trifluoromethyl)sulfonyl]benzene 
• 32858-96-1 2-Hydroxyphenyltrifluoromethylsulphone 
• 63641-17-8 1-methyl-2-((trifluoromethyl)sulfonyl)benzene 
• 79676-71-4 2-((trifluoromethyl)sulfonyl)benzaldehyde 

Relevant articles and documents

Three-Component Difunctionalization of Cyclohexenyl Triflates: Direct Access to Versatile Cyclohexenes via Cyclohexynes

Difunctionalization of strained cyclic alkynes presents a powerful strategy to build richly functionalized cyclic alkenes in an expedient fashion. Herein we disclose an efficient and flexible approach to achieve carbohalogenation, dicarbofunctionalization, aminohalogenation and aminocarbonation of readily available cyclohexenyl triflates. We have demonstrated the novel use of zincate base/nucleophile system for effective formation of key cyclohexyne intermediates and selective addition of various carbon and nitrogen nucleophiles. Importantly, leveraging the resulting organozincates enables the incorporation of a broad range of electrophilic partners to deliver structurally diverse cyclohexene motifs. The importance and utility of this method is also exemplified by the modularity of this approach and the ease in which even highly complex polycyclic scaffolds can be accessed in one step.

COMPOSITES, METHODS AND USES THEREOF

The present invention relates, in general terms, to methods of catalysing a reaction, including the steps of contacting a chemical entity comprising a sulphide moiety with a composite and an oxidant. The composite acts as a heterogeneous catalyst to oxidise the sulphide moiety. The present invention also relates to composites, methods of synthesising the composites and its use as a catalyst thereof.

Trifluoroalkyl sulfone compound preparation method

The invention provides a trifluoroalkyl sulfone compound preparation method, which comprises: continuously feeding a trifluoroalkyl thioether compound, sodium tungstate dihydrate and a hydrogen peroxide solution into a continuous reactor through feeding equipment, and carrying out an oxidation reaction on the trifluoroalkyl thioether compound to obtain a product system containing the trifluoroalkyl sulfone compound, wherein the trifluoroalkyl thioether compound has a structure represented by a structural formula, R is any one selected from the following groups: linear alkyl, branched alkyl, substituted aryl, non-substituted aryl, substituted heterocyclic aryl, non-substituted heterocyclic aryl, non-substituted cyclic alkyl and substituted cyclic alkyl, and the temperature of the oxidationreaction is 25-50 DEG C. According to the invention, by using the continuous feeding, the material contact effect is improved, so that the thioether oxidation reaction can be carried out at a low temperature; and the oxidation reaction temperature is reduced to effectively reduce the decomposition of hydrogen peroxide and reduce the pressure resistance requirement on the continuous reactor.