4272-12-2

Basic information

• Product Name: Propanoic acid, 3-(acetyloxy)-
• Synonyms: 3-acetoxy-propanoic acid;acetoxypropionic acid;3-acetoxy-propionic acid;3-acetoxypropanoic acid;3-acetoxypropionic acid;AcOCH2CH2COOH
• CAS NO: 4272-12-2
• Molecular Formula: C5H8O4
• Molecular Weight: 132.116
• Mol File: 4272-12-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 95 °C
• Boiling Point: 83-84 °C(Press: 0.4 Torr)
• Density: 1.1963 g/cm3(Temp: 25 °C)
• CAS DataBase Reference: Propanoic acid, 3-(acetyloxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 3-(acetyloxy)-(4272-12-2)
• EPA Substance Registry System: Propanoic acid, 3-(acetyloxy)-(4272-12-2)

Safety Data

• Hazardous Substances Data: 4272-12-2(Hazardous Substances Data)

Usage

Uses

3-Acetoxypropanoic Acid can be used for thermal degradation.

Upstream product

• 57-57-8 β-Propiolactone 
• 64-19-7 acetic acid 
• 18545-28-3 3-acetoxypropanal 
• 36678-05-4 6-hydroxy-3-oxa-2-hexanone 
• 108-24-7 acetic anhydride 
• 802294-64-0 propionic acid 
• 74-85-1 ethene 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 201230-82-2 carbon monoxide 
• 108-05-4 vinyl acetate 
• 503-66-2 3-hydroxypropionic acid 
• 3681-71-8 (Z)-3-Hexenyl acetate 
• 22094-23-1 2-acetoxypropanal 
• 79-10-7 acrylic acid 

Downstream Products

• 503-66-2 3-hydroxypropionic acid 
• 849585-22-4 LACTIC ACID 
• 52762-39-7 2-(3-Acetoxypropionyl)-cyclohexanon 
• 79-10-7 acrylic acid 
• 64-19-7 acetic acid 

Relevant articles and documents

Ligand-Enabled Monoselective β-C(sp3)-H Acyloxylation of Free Carboxylic Acids Using a Practical Oxidant

The development of C-H activation reactions that use inexpensive and practical oxidants remains a significant challenge. Until our recent disclosure of the β-lactonization of free aliphatic acids, the use of peroxides in C-H activation reactions directed by weakly coordinating native functional groups was unreported. Herein, we report C(sp3)-H β-acetoxylation and γ-, δ-, and ?-lactonization reactions of free carboxylic acids enabled by a novel cyclopentane-based mono-N-protected β-amino acid ligand. Notably, tert-butyl hydrogen peroxide is used as the sole oxidant for these reactions. This reaction has several key advantages over other C-H activation protocols: (1) exclusive monoselectivity was observed in the presence of two α-methyl groups; (2) aliphatic carboxylic acids containing α-hydrogens are compatible with this protocol; (3) lactonization of free acids, affording γ-, δ-, or ?-lactones, has been achieved for the first time.

Carbonylation of ethylenically unsaturated compounds

A process for the carbonylation of ethylenically unsaturated compounds including vinyl esters and a process for the production of 3-hydroxy propanoate esters or acids. The process comprises reacting said compound with carbon monoxide in the presence of a source of hydroxyl groups and of a catalyst system. The catalyst system is obtainable by combining: (a) a metal of Group 8, 9 or 10 or a compound thereof: and (b) a bidentate ligand of general formula (I): X1(X2)-Q2-A-R—B-Q1-X3(X4).

Gold(I)/copper(II)-cocatalyzed tandem cyclization/semipinacol reaction: Construction of 6-Aza/Oxa-Spiro[4.5]decane skeletons and formal synthesis of (±)-halichlorine

A simple and efficient strategy for the construction of 6-aza/oxa-spiro[4.5]decane skeletons under the cocatalysis of gold(I)/copper(II) was developed, and its potential utility was demonstrated by a formal synthesis of the biologically active marine alkaloid (±)-halichlorine.