503-66-2Relevant articles and documents
Lane,Heine
, p. 1348,1350 (1951)
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Bhattacharyya,Das
, p. 6715,6716, 6717 (1969)
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Efficient, chemical-catalytic approach to the production of 3-hydroxypropanoic acid by oxidation of biomass-derived levulinic acid with hydrogen peroxide
Wu, Linglin,Dutta, Saikat,Mascal, Mark
, p. 1167 - 1169 (2015)
3-Hydroxypropanoic acid (HPA), a precursor to acrylic acid, can be produced in high yield by oxidation of the biomass-derived platform chemical levulinic acid. While treatment of levulinic acid with H2O2 under acidic conditions gives predominantly succinic acid, a remarkable reversal of selectivity is observed under basic conditions, leading either directly to HPA or, under modified conditions, initially to 3-(hydroperoxy)propanoic acid, which can be quantitatively hydrogenated to HPA. Just say no to fermentation: The first selective, chemical-catalytic approach to renewable 3-hydroxypropanoic acid (HPA) has been accomplished by gentle oxidation of biomass-derived levulinic acid with hydrogen peroxide and hydrogenolysis of the resulting hydroperoxide intermediate. HPA is a green building block of major potential for the production of renewable acrylate derivatives.
The selective oxidation of glycerol over metal-free photocatalysts: insights into the solvent effect on catalytic efficiency and product distribution
Fan, Mingming,Haryonob, Agus,Jiang, Pingping,Leng, Yan,Yue, Chengguang,Zhang, Pingbo
, p. 3385 - 3392 (2021/06/06)
Selective oxidation of glycerol to high value-added derivatives is a promising biomass conversion pathway, but the related reaction mechanism, in particular the solvent effect, is rarely studied. In this work, O-doped g-C3N4was used as a metal-free catalyst to catalyze the selective oxidation of glycerol in different solvents. It was found that solvents can affect both catalytic efficiency and product distribution. A series of controlled experiments and theoretical calculation were applied to attest that the difference in interaction between glycerol and catalysts in different solvents is the main factor: competitive adsorption and hydrogen bond network from water inhibit the adsorption and activation of glycerol on the catalyst surface and reduce the conversion efficiency, while in acetonitrile, the stronger adsorption makes the oxidation reaction continue to yield esters. Two reaction routes in different solvents over O-doped g-C3N4are proposed for the first time, which is helpful for people to better understand the related reaction mechanism.
Expanding the repertoire of nitrilases with broad substrate specificity and high substrate tolerance for biocatalytic applications
Rayavarapu, Pratima,Shah, Shikha,Sunder, Avinash Vellore,Wangikar, Pramod P.
, p. 289 - 296 (2020/05/18)
Enzymatic conversion of nitriles to carboxylic acids by nitrilases has gained significance in the green synthesis of several pharmaceutical precursors and fine chemicals. Although nitrilases from several sources have been characterized, there exists a scope for identifying broad spectrum nitrilases exhibiting higher substrate tolerance and better thermostability to develop industrially relevant biocatalytic processes. Through genome mining, we have identified nine novel nitrilase sequences from bacteria and evaluated their activity on a broad spectrum of 23 industrially relevant nitrile substrates. Nitrilases from Zobellia galactanivorans, Achromobacter insolitus and Cupriavidus necator were highly active on varying classes of nitriles and applied as whole cell biocatalysts in lab scale processes. Z. galactanivorans nitrilase could convert 4-cyanopyridine to achieve yields of 1.79 M isonicotinic acid within 3 h via fed-batch substrate addition. The nitrilase from A. insolitus could hydrolyze 630 mM iminodiacetonitrile at a fast rate, effecting 86 % conversion to iminodiacetic acid within 1 h. The arylaliphatic nitrilase from C. necator catalysed enantioselective hydrolysis of 740 mM mandelonitrile to (R)-mandelic acid in 4 h. Significantly high product yields suggest that these enzymes would be promising additions to the suite of nitrilases for upscale biocatalytic application.
Method used for producing 3-hydroxypropionic acid
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Paragraph 0037; 0045-0047; 0050-0052; 0053-0055, (2019/12/08)
The invention belongs to the technical field of chemistry, and more specifically provides a method used for producing 3-hydroxypropionic acid. The method comprises following steps: 1, under catalyst effect, hydrogen cyanide and ethylene oxide are reacted to generated 3-hydroxypropionitrile; 2, an acid is added into the 3-hydroxypropionitrile prepared using step 1 for hydrolysis, and 3-hydroxypropionic acid and an inorganic slat are generated through reaction; 3, a reaction solution obtained in step 2 is subjected to continuous chromatography separation to obtain 3-hydroxypropionic acid and aninorganic salt solution, and the inorganic salt solution is subjected to concentration to obtain a by-product. According to the method, continuous chromatography method is adopted to process the 3-hydroxypropionitrile hydrolysis reaction solution, so that the amounts of waste water, waste gas, and waste residue can be reduced effectively, high content of the target product is obtained at high yield, and production cost is reduced.