4281-40-7

Basic information

• Product Name: 6,7-DIMETHOXY-4-METHYLCOUMARIN
• Synonyms: TIMTEC-BB SBB006391;4-METHYL-6,7-DIMETHOXYCOUMARIN;6,7-DIMETHOXY-4-METHYLCOUMARIN;DIMETHOXY-4-METHYLCOUMARIN,6,7-;6,7-DIMETHOXY-4-METHYLCOUMARIN, FOR FLUO RESCENCE;DIMETHOXY-4-METHYLCOUMARIN,6,7-(RG);6,7-dimethoxy-4-methyl-chromen-2-one;6,7-dimethoxy-4-methylchromen-2-one
• CAS NO: 4281-40-7
• Molecular Formula: C12H12O4
• Molecular Weight: 220.22
• Product Categories: Fluorescent Labels and Indicators;Fluorescent Labels & Indicators;Fluorescent Enzyme Substrates for Flow CytometryBiochemicals and Reagents;Luminescent Compounds/Detection;Stains and Dyes;Fluorescent Enzyme Substrates for Flow Cytometry;Building Blocks;CoumarinsFluorescent Probes, Labels, Particles and Stains;Fluorescent Enzyme Substrates;Heterocyclic Building Blocks
• Mol File: 4281-40-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 136-139 °C(lit.)
• Boiling Point: 374.5°Cat760mmHg
• Flash Point: 168.2°C
• Appearance: /
• Density: 1.202g/cm³
• Vapor Pressure: 8.34E-06mmHg at 25°C
• Refractive Index: 1.544
• Solubility: DMSO: soluble
• BRN: 189644
• CAS DataBase Reference: 6,7-DIMETHOXY-4-METHYLCOUMARIN(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DIMETHOXY-4-METHYLCOUMARIN(4281-40-7)
• EPA Substance Registry System: 6,7-DIMETHOXY-4-METHYLCOUMARIN(4281-40-7)

Safety Data

• WGK Germany: 3
• F: 8
• Hazardous Substances Data: 4281-40-7(Hazardous Substances Data)

Usage

Uses

6,7-Dimethoxy-4-methylcoumarin (cas# 4281-40-7) is a compound useful in organic synthesis.

InChI:InChI=1/C12H12O4/c1-7-4-12(13)16-9-6-11(15-3)10(14-2)5-8(7)9/h4-6H,1-3H3

Upstream product

• 2033-89-8 3,4-dimethoxyphenol 
• 623-43-8 methyl crotonate 
• 7203-46-5 3,4-dimethoxyphenyl acetate 
• 529-84-0 6,7-dihydroxy-4-methylcoumarin 
• 74-88-4 methyl iodide 
• 6345-62-6 6-hydroxy-7-methoxyl-4-methylcoumarin 
• 2555-28-4 4-methyl-7-methoxy-2H-1-benzopyran-2-one 
• 533-73-3 1,2,4-Trihydroxybenzene 
• 7664-93-9 sulfuric acid 
• 67-64-1 acetone 
• 77-78-1 dimethyl sulfate 
• 88404-25-5 4-(bromomethyl)-6,7-dimethoxy-2-oxo-2H-chromene 

Downstream Products

• 100258-10-4 3-(2-hydroxy-4,5-dimethoxy-phenyl)-butyric acid 

Relevant articles and documents

Rh-Catalyzed Synthesis of Coumarin Derivatives from Phenolic Acetates and Acrylates via C-H Bond Activation

An efficient annulation strategy involving the reaction of phenolic acetates with acrylates in the presence of [Rh2(OAc)4] as catalyst and formic acid as reducing agent, leading to the high yield synthesis of coumarin derivatives, has been developed. The addition of NaOAc as a base increased the yield of the products. The reaction is quite successful for both electron-rich as well as electron-deficient phenolic acetates, affording coumarins with excellent regioselectivity, and proceeds via C-H bond activation proven by deuterium incorporation studies.

Free radical chemistry associated with H(RSiH) nH

Polysilanes of the type H(RSiH)nH, where R = n-hexyl or phenyl, have been used as radical-based reducing agents for organic halides. They rival the effectiveness of the other group 14 hydrides in reduction processes. The repetitive hydrogen transfer from the same molecule of H(RSiH)nH allows these compounds to be used in small quantities. Lower (5 × 104 M-1 s-1) and higher (6 × 105 M-1 s-1) limit values for the rate constant of the reaction of primary alkyl radicals with each SiH moiety of H(PhSiH)nH have been obtained by using unimolecular radical reactions as timing devices. The photochemical behavior of these polysilanes in the presence or absence of di-tert-butyl peroxide have been studied by EPR spectroscopy, and the -SiHR-SiR-SiHR radical (R = n-hexyl) has been identified as a transient species. Silyl radicals, obtained from H(RSiH)nH and thermally generated tert-butoxyl radicals, add to a variety of substrates containing double bonds to give the corresponding adducts for which EPR spectra have been recorded.

New fragmentation pathways in the EIMS of 4-methylcoumarins useful in their identification

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