42893-53-8Relevant articles and documents
Novel natural product-based cinnamates and their thio and thiono analogs as potent inhibitors of cell adhesion molecules on human endothelial cells
Kumar, Sarvesh,Singh, Brajendra K.,Arya, Pragya,Malhotra, Shashwat,Thimmulappa, Rajesh,Prasad, Ashok K.,Van Der Eycken, Erik,Olsen, Carl E.,Depass, Anthony L.,Biswal, Shyam,Parmar, Virinder S.,Ghosh, Balaram
experimental part, p. 5498 - 5511 (2011/12/15)
In the present study, we report the design and synthesis of novel analogs of cinnamates, thiocinnamates and thionocinnamates and evaluated the potencies of these analogs to inhibit TNF-α induced ICAM-1 expression on human endothelial cells. By using whole cell-ELISA, our screening data demonstrated that ethyl 3′,4′,5′-trimethoxythionocinnamate (ETMTC) is the most potent inhibitor of TNF-α induced ICAM-1, VCAM-1 and E-selectin. As functional consequences, ETMTC abrogated TNF-α induced adhesion of neutrophils to the endothelial monolayer. Structure-activity relationship studies revealed the critical role of the chain-length of the alkyl group in the alcohol moiety, number of methoxy groups in the aromatic ring of the cinnamoyl moiety and the presence of the α, β- C-C double bond in the thiocinnamates and thionocinnamates.
Synthesis of thioesters by simultaneous activation of carboxylic acids and alcohols using PPh3/NBS with benzyltriethylammonium tetrathiomolybdate as the sulfur transfer reagent
Gopinath, Purushothaman,Vidyarini, Ravindran Sasitha,Chandrasekaran, Srinivasan
experimental part, p. 6043 - 6047 (2010/03/25)
A new and simple route for the synthesis of thioesters starting from carboxylic acids and alcohols is reported by using tetrathiomolybdate as the key sulfur transfer reagent, Triphenylphosphane and N-bromosuccinimide were used for the activation of the ca
New α-Sulfinyl-thioesters, as Precursors to Thioacrylates
Wladislaw, B.,Marzorati, L.,Gruber, J.
, p. 2937 - 2944 (2007/10/02)
Several substituted α-sulfinyl thioacetates, prepared by α-alkylation and α-sulfur oxidation methods, gave by thermal decomposition thioacrylates.
