42982-49-0

Basic information

• Product Name: 19-Norpregna-5(10),9(11)-diene-3,20-dione, 17-hydroxy-, cyclic 3-(1,2-ethanediyl acetal)
• Synonyms: 19-Norpregna-5(10),9(11)-diene-3,20-dione, 17-hydroxy-, cyclic 3-(1,2-ethanediyl acetal);17-Hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione cyclic 3-(1,2-ethanediyl acetal);3-(Ethylene-dioxy)-17α-hydroxy-19-norpregna-5(10),9(11)-diene-20-one;3-(Ethylene-dioxy)-17alpha-hydroxy-19-norpregna-5(10),9(11)-diene-20-one
• CAS NO: 42982-49-0
• Molecular Formula: C₂₂H₃₀O₄
• Molecular Weight: 358.4712
• EINECS: -0
• Product Categories: API
• Mol File: 42982-49-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 534.5±50.0 °C(Predicted)
• Appearance: /
• Density: 1.23
• PKA: 12.94±0.40(Predicted)
• CAS DataBase Reference: 19-Norpregna-5(10),9(11)-diene-3,20-dione, 17-hydroxy-, cyclic 3-(1,2-ethanediyl acetal)(CAS DataBase Reference)
• NIST Chemistry Reference: 19-Norpregna-5(10),9(11)-diene-3,20-dione, 17-hydroxy-, cyclic 3-(1,2-ethanediyl acetal)(42982-49-0)
• EPA Substance Registry System: 19-Norpregna-5(10),9(11)-diene-3,20-dione, 17-hydroxy-, cyclic 3-(1,2-ethanediyl acetal)(42982-49-0)

Safety Data

• Hazardous Substances Data: 42982-49-0(Hazardous Substances Data)

Usage

General Description

The chemical "19-Norpregna-5(10),9(11)-diene-3,20-dione, 17-hydroxy-, cyclic 3-(1,2-ethanediyl acetal)" is a synthetic progestin compound that is derived from the hormone progesterone. It is commonly used as an active ingredient in hormonal contraceptives, such as birth control pills and contraceptive patches. This chemical works by inhibiting ovulation and altering the cervical mucus and uterine lining to prevent pregnancy. It may also be used to regulate menstrual cycles and treat menstrual disorders, as well as in hormone replacement therapy for menopausal women. However, it is important to note that this chemical should only be used under the guidance of a healthcare professional, as it may have potential side effects and interactions with other medications.

Upstream product

• 124-38-9 carbon dioxide 
• 5490-76-6 (8S,13S,14S,17R)-17-ethynyl-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2’-[1,3]dioxolan]-17-ol 
• 917-54-4 methyllithium 
• 290825-36-4 3,3-ethylenedioxy-17β-cyano-17α-chloromethyl(dimethyl)siloxy estren-5(10),9(11)diene 
• 5571-36-8 ethylene deltenone 
• 54690-63-0 17β-cyano-3,3-[1,2-ethanediylbis(oxy)]-17α-trimethylsilyloxyestra-5(10),9(11)-diene 
• 75-16-1 methylmagnesium bromide 
• 960078-87-9 3,3-dimethoxy-17α-hydroxy-20-methoxy-19-norpregn-5(10),9(11),20-trien 

Downstream Products

• 14340-04-6 17α-acetoxy-19-norpregna-4,9-diene-3,20-dione 
• 54201-83-1 5α,10α-epoxy-17α-hydroxy-19-norpregn-9(11)-ene-3,20-dione 3,20-bis(ethylene acetal) 
• 54201-84-2 17α-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione 3,20-bis(ethylene acetal) 

Relevant articles and documents

Synthesis method of ulipristal acetate intermediate

The invention provides a synthesis method of a ulipristal acetate intermediate. The synthesis method of the ulipristal acetate intermediate comprises the following steps: 1) a cyano reaction: dissolving a 3-ketal compound (I) in ethyl acetate, adding acetone cyanohydrin and triethylamine, and carrying out reacting to obtain a 17-cyanohydrin compound (II); 2) a protective reaction: adding dichloromethane, imidazole and a silanization reagent into a wet product of the 17-cyanohydrin compound (II), keeping the above raw materials at a temperature of 20-25 DEG C until the raw materials react completely so as to obtain a protected compound (III); 3) a methylation reaction: adding an ether solvent into a wet product of the protected compound (III), controlling a temperature to be -10 DEG C to 5DEG C, dropwise adding a lithium methide solution, carrying out a reaction with a temperature controlled to be -40 DEG C to 5 DEG C until the raw materials are completely reacted so as to obtain a methide (IV-1) solution; and 4) a ketalation reaction: adding ethylene glycol, triethyl orthoformate and p-toluenesulfonic acid (PTS) into the methide (IV-1) solution, and carrying out a heat-preserved reaction at a temperature of 20-25 DEG C until the raw materials are completely reacted so as to obtain a diketal (V).

20-ketofatty -11β-arylpropionic agonists or antagonists and having its deriv. nonsteroid antiandrogenic characteristics

The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.

17β-acyl-17α-propynyl-11β-(cyclic amino) aryl steroids and their derivatives having antagonist hormonal properties

The invention is directed to a novel class of 17β-acyl-17α-propynyl steroids which exhibit potent antiprogestational activity.