54201-84-2

Basic information

• Product Name: 3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol
• Synonyms: 3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol;17-Hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione cyclic bis(1,2-ethanediyl acetal);3,3,20,20-Bis(ethylene-dioxy)-17α-hydroxy-19-norpregna-5(10),9(11)-diene;3,3,20,20-bis(ehtylene-dioxy)-17a-hydroxy-19-norpregna-5(10),9(11)-diene;19-Norpregna-5(10),9(11)-diene-3,20-dione,17-hydroxy-, cyclic 3,20-bis(1,2-ethanediyl acetal), (5a,10a)-;3,3,20,20-Bis(ethylene-dioxy)-17α-hydroxy-19/;17-hydroxy-19-norpregna-5(10),9(11)-diene-3,20-dione 3,20-bis(ethylene acetal);3,20-BIS(ETHYLENEDIOXY)-19-NORPREGNA-5(10),9(11)-DIENE-17-OL
• CAS NO: 54201-84-2
• Molecular Formula: C₂₄H₃₄O₅
• Molecular Weight: 402.52376
• EINECS: 1308068-626-2
• Product Categories: API
• Mol File: 54201-84-2.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 568 °C at 760 mmHg
• Flash Point: 297.3 °C
• Appearance: /
• Density: 1.25
• PKA: 14.95±0.40(Predicted)
• CAS DataBase Reference: 3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol(54201-84-2)
• EPA Substance Registry System: 3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol(54201-84-2)

Safety Data

• Hazardous Substances Data: 54201-84-2(Hazardous Substances Data)

Usage

General Description

3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol is a synthetic compound with a complex chemical structure. It belongs to the class of steroids and is specifically a norpregnane derivative. The compound contains two ethylenedioxy groups and a hydroxyl group, and its molecular formula is C25H32O4. It is often used in the field of medicinal chemistry and pharmaceutical research for its potential biological activities, especially in relation to hormone receptors and related pathways. The compound may have potential applications in the development of new drugs for hormone-related conditions and diseases.

Upstream product

• 107-21-1 ethylene glycol 
• 5490-76-6 (8S,13S,14S,17R)-17-ethynyl-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2’-[1,3]dioxolan]-17-ol 
• 2503-06-2 estra-4,9-diene-3,17-dione 

Downstream Products

• 54201-83-1 C₂₄H₃₄O₆ 
• 25092-42-6 (11β,17α)-17-hydroxy-11-methyl-norpregna-4-en-3,20-dione 
• 14340-01-3 17α-hydroxy-19-norpregna-4(5),9(10)-diene-3,20-dione 
• 54201-83-1 5α,10α-epoxy-17α-hydroxy-19-norpregn-9(11)-ene-3,20-dione 3,20-bis(ethylene acetal) 
• 244206-54-0 C₃₄H₅₁NO₆Si 
• 244206-51-7 3,20-bis-ethylenedioxy-5α,17α-dihydroxy-11β-(4-aminophenyl)-19-norpregn-9-ene 
• 244206-53-9 11β-(4-N-trifluoroacetamidophenyl)-17α-acetoxy-19-norpregna-4,9-diene-3,20-dione 
• 244206-56-2 17α-acetoxy-11β-(4-N-acetyl-N-methylaminophenyl)-19-norpregna-4,9-diene-3,20-dione 
• 244206-52-8 11β-(4-aminophenyl)-17α-hydroxy-19-norpregna-4,9-diene-3,20-dione 
• 159681-67-1 11β-(4-N-methylaminophenyl)-17α-hydroxy-19-norpregna-4,9-diene-3,20-dione 
• 126690-41-3 3,3,20,20-bis(ethylene-dioxy)-5α-17α-dihydroxy-11β-[4-(N,N-dimethylamino)-phenyl-]-19-norpregna-9(11)-ene 
• 159811-51-5 CDB-3236 

Relevant articles and documents

Environmentally-friendly synthesis method of ulipristal acetate intermediate and ulipristal acetate

The invention provides a method for environmentally-friendly synthesis of an ulipristal acetate intermediate and ulipristal acetate. According to the invention, a compound 2 is used as a starting rawmaterial, and reacts with acetylene in a solvent to form an alkynyl alcohol compound intermediate 3, a hydration reaction is performed with water under the catalysis of an ionic liquid and CO2 to obtain an intermediate 4, the intermediate 4 is subjected to carbonyl protection to obtain an intermediate 5, and the intermediate 5 is subjected to double bond epoxidation, a Grignard reaction, decarbonylation protection and acetylation to obtain the high-purity ulipristal acetate. The method is environment-friendly, convenient in steps, mild in conditions, low in cost, easy to amplify and suitable for industrial production, and the solvent can be recycled.

Preparation method of ulipristal acetate diketal

The invention discloses a preparation method of ulipristal acetate diketal. Dihydroxyprogesterone dehydrogenate 1 is used as the raw material to prepare an important intermediate of sterides, namely ulipristal acetate diketal 8; a reaction formula is shown in the attached figure. The preparation method has the advantages that the dihydroxyprogesterone dehydrogenate 1 is used as a starting raw material, seven steps are performed, and the ulipristal acetate diketal with weight total yield rate of 65% or above can be obtained; the reaction is simple, the selectivity is good, and the preparation method is suitable for industrialization production.

Method for preparing di-ketal

The invention discloses a method for preparing di-ketal. An open-loop substance 1 used as a raw material is subjected to cyanide reaction, ketalation, etherifying reaction, oxidization, decarboxylic reaction, diene reaction and di-ketal reaction to obtain di-ketal 9, and reaction formulas are as follows: as shown in the description.