43071-52-9

Basic information

• Product Name: 2-ACETYL-7-METHOXYBENZOFURAN
• Synonyms: 1-(7-Methoxy-1-benzofuran-2-yl)ethanone;1-(7-methoxy-2-benzofuranyl)-ethanon;1-(7-methoxy-2-benzofuranyl)ethanone;7-Methoxy-2-benzofuranyl methyl ketone;7-methoxy-2-benzofuranylmethylketone;Ethanone, 1-(7-methoxy-2-benzofuranyl)-;ketone,7-methoxy-2-benzofuranylmethyl;1-(7-METHOXY-1-BENZOFURAN-2-YL)-1-ETHANONE
• CAS NO: 43071-52-9
• Molecular Formula: C₁₁H₁₀O₃
• Molecular Weight: 190.2
• Product Categories: Heterocycles;Furan&Benzofuran;Benzofurans;Building Blocks;Heterocyclic Building Blocks
• Mol File: 43071-52-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 94-96 °C(lit.)
• Boiling Point: 180 °C / 15mmHg
• Flash Point: 135.404 °C
• Appearance: white to light yellow crystal powder
• Density: 1.1752 (rough estimate)
• Vapor Pressure: 0.00113mmHg at 25°C
• Refractive Index: 1.5854 (estimate)
• CAS DataBase Reference: 2-ACETYL-7-METHOXYBENZOFURAN(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ACETYL-7-METHOXYBENZOFURAN(43071-52-9)
• EPA Substance Registry System: 2-ACETYL-7-METHOXYBENZOFURAN(43071-52-9)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: OB4571050
• Hazardous Substances Data: 43071-52-9(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

Uses

2-Acetyl-7-methoxybenzofuran is a building block that has been used as a reagent for the preparation of 2-ethylbenzofuran derivatives to be used as potent human uric acid transporter 1 (hURAT1) inhibitors.

InChI:InChI=1/C11H10O3/c1-7(12)10-6-8-4-3-5-9(13-2)11(8)14-10/h3-6H,1-2H3

Upstream product

• 638-07-3 ethyl (2-chloroaceto)acetate 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 

Downstream Products

• 102234-44-6 2-ethyl-7-methoxybenzo[b]furan 
• 478248-83-8 1-(7-methoxy-benzofuran-2-yl)-ethanone oxime 
• 260786-00-3 1-(7-methoxybenzofuran-2-yl)ethanol 
• 40020-87-9 2-acetyl-7-hydroxybenzofuran 
• 1619229-32-1 (Z)-1-(3-(1,2-diphenylvinyl)-7-methoxybenzofuran-2-yl)ethanone 
• 1619229-31-0 (E)-1-(3-(1,2-diphenylvinyl)-7-methoxybenzofuran-2-yl)ethanone 
• 1292843-03-8 (6-bromo-2-ethyl-7-hydroxybenzofuran-4-yl)(4-methoxyphenyl)methanone 
• 1292843-00-5 (6-bromo-2-ethyl-7-hydroxybenzofuran-4-yl)(3,5-dibromo-4-hydroxyphenyl)methanone 
• 1292842-93-3 (2-ethyl-7-hydroxybenzofuran-4-yl)(4-hydroxyphenyl)methanone 
• 1292842-92-2 (2-ethyl-7-hydroxybenzofuran-4-yl)(4-methoxyphenyl)methanone 
• 1292842-91-1 (2-ethyl-7-hydroxybenzofuran-3-yl)(4-methoxyphenyl)methanone 
• 1292842-79-5 (2-ethyl-7-methoxybenzofuran-4-yl)(4-methoxyphenyl)methanone 

Relevant articles and documents

SYNTHESIS AND APPLICATION OF IMIDAZOLE DERIVATIVES. SYNTHESIS OF (1-METHYL-1H-IMIDAZOL-2-YL)METHANOL DERIVATIVES AND CONVERSION INTO CARBONYL COMPOUNDS

(1-methyl-2H-imidazol-2-yl)methanol derivatives ( 4 and 7 ) were prepared by treating carbonyl compounds with 2-lithio-1-methyl-1H-imidazole ( 2 ) or by treating 2-acyl-1H-imidazoles ( 3 ) with organometallic reagents or sodium borohydride.The alcohols ( 4 and 7 ) were convertible into the carbonyl compounds via the corresponding quaternary salts ( 8 and 10 ).The stable (1-methyl-1H-imidazol-2-yl)methanol system, , can be regarded as a masked form of the carbonyl group as well as a synthon of the group.Keywords - (1-methyl-1H-imidazol-2-yl)methanol; 2-acyl-1-methyl-1H-imidazole; carbonyl compound synthesis; β-ketoester; protecting group; latent functionality; symmetric ketone; dihydrojasmone