433716-67-7

Basic information

• Product Name: 2-Propanone, 1-[6-(4-nitrobenzoyl)-1,3-benzodioxol-5-yl]-
• CAS NO: 433716-67-7
• Molecular Formula: C17H13NO6
• Molecular Weight: 327.293
• Mol File: 433716-67-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Propanone, 1-[6-(4-nitrobenzoyl)-1,3-benzodioxol-5-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanone, 1-[6-(4-nitrobenzoyl)-1,3-benzodioxol-5-yl]-(433716-67-7)
• EPA Substance Registry System: 2-Propanone, 1-[6-(4-nitrobenzoyl)-1,3-benzodioxol-5-yl]-(433716-67-7)

Safety Data

• Hazardous Substances Data: 433716-67-7(Hazardous Substances Data)

Upstream product

• 4676-39-5 1-(1,3-benzodioxol-5-yl)-2-propanone 
• 62-23-7 4-nitro-benzoic acid 
• 4023-82-9 4-nitrobenzoylacetone 
• 717903-52-1 6-(trimethylsilyl)benzo[d][1,3]dioxol-5-yl triflate 
• 6974-61-4 β-oxy-α-(3',4'-methylenedioxyphenyl)propane 
• 94-59-7 1-allyl-3,4-methylenedioxybenzene 

Downstream Products

• 433716-68-8 3-methyl-6,7-methylenedioxy-1-(4-nitrophenyl)isoquinoline 
• 102771-27-7 5-(4-nitrophenyl)-8-methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepine 
• 114460-08-1 GYKI 52895 
• 102771-26-6 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine 
• 501328-38-7 [6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-benzo[1,3]dioxol-5-yl]-(4-nitro-phenyl)-methanone 
• 501328-41-2 [6-(2-methyl-[1,3]dioxolan-2-ylmethyl)-benzo[1,3]dioxol-5-yl]-(4-nitro-phenyl)-methanol 
• 501328-42-3 7-methyl-5-(4-nitrophenyl)-5H-1,3-dioxolo[4,5-g][2]benzopyran 

Relevant articles and documents

Synthesis of 2,3-benzodiazepines and 2,3-benzodiazepin-4-ones from arynes and β-diketones

2,3-Benzodiazepines were synthesized by two-step or one-pot reactions from aryne precursors. Reaction of 2- (trimethylsilyl)aryl triflates with β-diketones in the presence of CsF gave ortho-substituted benzophenones. Treatment of benzophenones with hydrazine hydrate resulted in the formation of 2,3-benzodiazepines in moderate yields. Tofisopam, a well known anxiolytic, could be synthesized via C-C bond insertion of 3,4-dimethoxybenzyne with 2-ethyl-1-(3,4-dimethoxyphenyl)butane-1,3-dione, followed by the reaction with hydrazine hydrate in one-pot operation. 2,3-Benzodiazepin-4-ones were also synthesized by the reaction of β-keto esters with triflates in the presence of CsF, followed by the addition of hydrazine hydrate. Substituted isoquinolines were synthesized by the reaction of ortho-substituted benzophenones with ammonium hydroxide.

A simple and efficient synthesis of GYKI 52466 and GYKI 52895

The synthesis of 1-(4-aminophenyl)-4-methyl-7,8-methylene-dioxy-5H-2,3-benzodiazepine (GYKI 52466, 1), the prototype of a series of noncompetitive AMPA receptor antagonists, and its 3,4-dihydroderivative (GYKI 52895, 2) is described. The title compounds have been prepared starting from safrole through a quite effective procedure.