4352-63-0

Basic information

• Product Name: NAPHTHO[2,1-B]FURAN-2(1H)-ONE
• Synonyms: NAPHTHO[2,1-B]FURAN-2(1H)-ONE;1H-benzo[e][1]benzofuran-2-one;1H-benzo[e]benzofuran-2-one;1,2-Dihydro-2-oxonaphtho[2,1-b]furan
• CAS NO: 4352-63-0
• Molecular Formula: C₁₂H₈O₂
• Molecular Weight: 184.19
• Mol File: 4352-63-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 104-106°C
• Boiling Point: 366.2°Cat760mmHg
• Flash Point: 153.3°C
• Appearance: /
• Density: 1.313g/cm³
• Vapor Pressure: 1.48E-05mmHg at 25°C
• Refractive Index: 1.686
• CAS DataBase Reference: NAPHTHO[2,1-B]FURAN-2(1H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: NAPHTHO[2,1-B]FURAN-2(1H)-ONE(4352-63-0)
• EPA Substance Registry System: NAPHTHO[2,1-B]FURAN-2(1H)-ONE(4352-63-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 4352-63-0(Hazardous Substances Data)

Usage

General Description

Naphtho[2,1-b]furan-2(1h)-one, also known as beta-Naphthofuranone, is a chemical compound that is associated with the furan substance class. It typically appears as a solid and has a distinct aromatic scent. NAPHTHO[2,1-B]FURAN-2(1H)-ONE contains a naphtho[2,1-b]furan-2(1H)-one skeleton, with the furan ring being oxygenated at position 2 to give a ketone. Naphtho[2,1-b]furan-2(1h)-one participates in a variety of chemical reactions and is used in chemical synthesis and research. While information regarding its safety and toxicity is somewhat limited, it's important to handle this substance with proper safety precautions.

InChI:InChI=1/C12H8O2/c13-12-7-10-9-4-2-1-3-8(9)5-6-11(10)14-12/h1-6H,7H2

Upstream product

• 10441-45-9 2-(2-hydroxynaphthalen-1-yl)acetic acid 
• 10441-48-2 (2-methoxy-[1]naphthyl)-acetic acid 
• 120-23-0 (2-naphthoyl)oxyacetic acid 
• 86-87-3 naphth-1-yl acetic acid 
• 5121-00-6 naphthalen-1-yl-acetyl chloride 
• 86-86-2 1-Naphthylacetamide 
• 135-19-3 β-naphthol 
• 93-04-9 2-Methoxynaphthalene 
• 854817-54-2 α-hydroxy-1-(2-methoxynaphthalene)acetonitrile 
• 195210-69-6 N,N-diethyl-1-methyl-2-carbamoyloxynaphthalene 
• 61912-14-9 2-naphthyl diethylcarbamate 
• 131543-46-9 Glyoxal 
• 133523-53-2 1,2-dihydronaphtho<2,1-b>furan-1,2-diol 
• 67-64-1 acetone 

Relevant articles and documents

Preparation and stereochemistry of the isopropylidene derivatives of 1,2-dihydronaphtho[2,1-b]furan-1,2-diol and 1,2,9,10-tetrahydronaphtho[2,1-b:7, 8-b′] difuran-1,2,9,10-tetraol in comparison with the corresponding acetyl derivatives

1,2-Dihydronaphtho[2,1-b]furan-1,2-diol and 1,2,9,10-tetrahydronaphtho[2,1- b:7,8-b′]difuran-1,2,9,10-tetraol were transformed into the corresponding isopropylidene derivatives, which were studied mainly by 1H NMR and chiral HPLC analyses in terms of a possible transformation mechanism and stereochemistry in comparison with their corresponding acetyl derivatives.

Pd(OAc)2-catalyzed lactonization of arylacetamides involving oxidation of C-H bonds

The reaction of arylacetamides that contain a quinolin-8-ylmethylamine as the directing group with PhI(OAc)2, in the presence of Pd(OAc)2 as the catalyst, results in lactonization to give γ-lactones, the formation of which involves activation of the ortho C-H bonds, with concomitant cleavage of the directing group.

2-(2-Hydroxyaryl)cinnamic amides: a new class of axially chiral molecules

The syntheses of several differently substituted amides formally derived from a chiral amine, either E-2-(2-hydroxyphenyl)cinnamic acid or both E- and Z-2-(2-hydroxynaphthyl)cinnamic acid, are reported. These molecules display a restricted rotation about