435273-75-9

Basic information

• Product Name: Indacaterol interMediate
• Synonyms: (R)-5-[2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)aMino]-1-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one;(R)-5-[2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)quinolin-2(1H)-one;(R)-8-(benzyloxy)-5-(2-(5,6-diethyl-2,3-dihydro-1H-inden-2-ylaMino)-1-hydroxyethyl)quinolin-2(1H)-one;(R)-8-(Benzyloxy)-5-(2-((5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino)-1-hydroxyethyl)quinolin-2(1;(R)-8-(Benzyloxy)-5-(2-((5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino)-1-hydroxyethyl)quinolin-;Indacaterol Impurity 8;(R)-8-benzyloxy-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-1H-quinolin-2-one;5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-phenylmethoxy-1H-quinolin-2-one
• CAS NO: 435273-75-9
• Molecular Formula: C₃₁H₃₄N₂O₃
• Molecular Weight: 482.61326
• Mol File: 435273-75-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 734.1±60.0 °C(Predicted)
• Appearance: /
• Density: 1.23
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 10.86±0.70(Predicted)
• CAS DataBase Reference: Indacaterol interMediate(CAS DataBase Reference)
• NIST Chemistry Reference: Indacaterol interMediate(435273-75-9)
• EPA Substance Registry System: Indacaterol interMediate(435273-75-9)

Safety Data

• Hazardous Substances Data: 435273-75-9(Hazardous Substances Data)

Usage

Uses

5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone is used as a reactant in the preparation of Indacaterol (I499745), a β-adrenoreceptor agonist.

Upstream product

• 312753-70-1 5,6-diethyl-2,3-dihydro-1H-inden-2-amine 
• 65-85-0 benzoic acid 
• 173140-90-4 (R)-5-(2-oxiranyl)-8-benzyloxy-2(1H)-quinolinone 
• 312753-53-0 5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride 
• 100-39-0 benzyl bromide 
• 93609-84-8 5-acetyl-8-benzyloxy-1H-quinolin-2-one 
• 62978-73-8 5-acetyl-8-hydroxy-2(1H)-quinolinone 
• 530084-79-8 8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one 
• 774222-23-0 5-(R)-(2-amino-1-hydroxy-ethyl)-8-phenylmethoxy-(1H)-quinolin-2-one 
• 100331-89-3 8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one 
• 100331-91-7 5-(2,2-Dihydroxyacetyl)-8-(benzyloxy)-carbostyril 

Downstream Products

• 753498-25-8 indacaterol maleate 
• 312753-06-3 indacaterol 
• 753498-25-8 indacaterol maleate 
• 1585235-03-5 8-(phenylmethoxy)-5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-(1H)-quinolin-2-one dibenzoyl-L-tartrate 
• 753498-33-8 8-(phenylmethoxy)-5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-(1H)-quinolin-2-one tartrate 

Relevant articles and documents

Preparation method of indacaterol and salt thereof

The invention relates to a preparation method of indacaterol and a salt thereof. The preparation method comprises the following steps: in a solvent, reacting a mixture containing a compound as shown in a formula I with m-chlorobenzoic acid to obtain a com

Preparation method for indacaterol maleate

The invention specifically relates to a preparation method for indacaterol maleate, belonging to the field of drug synthesis. The preparation method is simple and short in steps, easy to operate, safe, friendly to environment and fee of an alkaline solution; after a heating reaction, a coupled product in the step 1) can be obtained, and the amount of produced regioisomers, dimers and other by-products is small; the yield of the product indacaterol maleate is high, as high as 93%, and the HPLC purity of the product indacaterol maleate is more than 97.8%; post-treatment is simple, and industrialproduction of indacaterol maleate is facilitated; and the product indacaterol maleate is high in optical purity.

A new method of [...]dutrow

The present invention discloses a new method for synthesizing indacaterol. The present invention provides a completely-new indacaterol synthesis method. Compared with the known method in the prior art, the method of the present invention has the following characteristics that: the easily available starting raw material is adopted, the side reaction is less when the two raw material fragments dock, the reaction conditions of the route are mild, the route is short, the yield is high, and the market competitiveness is provided.