774222-23-0

Basic information

• Product Name: 5-(R)-(2-amino-1-hydroxy-ethyl)-8-phenylmethoxy-(1H)-quinolin-2-one
• Synonyms: 5-(R)-(2-amino-1-hydroxy-ethyl)-8-phenylmethoxy-(1H)-quinolin-2-one
• CAS NO: 774222-23-0
• Molecular Weight: 310.353
• Mol File: 774222-23-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(R)-(2-amino-1-hydroxy-ethyl)-8-phenylmethoxy-(1H)-quinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(R)-(2-amino-1-hydroxy-ethyl)-8-phenylmethoxy-(1H)-quinolin-2-one(774222-23-0)
• EPA Substance Registry System: 5-(R)-(2-amino-1-hydroxy-ethyl)-8-phenylmethoxy-(1H)-quinolin-2-one(774222-23-0)

Safety Data

• Hazardous Substances Data: 774222-23-0(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 93609-84-8 5-acetyl-8-benzyloxy-1H-quinolin-2-one 
• 62978-73-8 5-acetyl-8-hydroxy-2(1H)-quinolinone 
• 530084-79-8 8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one 
• 100331-89-3 8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one 
• 1254102-12-9 (R)-5-(2-azido-1-hydroxyethyl)-8-(benzyloxy)quinolin-2(1H)-one 
• 774222-22-9 8-benzyloxy-5-(R-2-{[(2,4-dimethoxyphenyl)-(2-methoxyphenyl)methyl]amino}-1-hydroxyethyl)-1H-quinolin-2-one 

Downstream Products

• 435273-75-9 (R)-8-(benzyloxy)-5-[2-[(5,6-diethyl-2,3-dihydro-1H-indole-2-yl)amino]-1-hydroxyethyl]quinolin-2(1H)-one 
• 312753-06-3 indacaterol 
• 753498-25-8 indacaterol maleate 

Relevant articles and documents

A Process for Preparing Indacaterol and Salts Thereof

The present invention relates to a process for preparing indacaterol or salts thereof. The process comprises of forming compound of Formula 1 by reacting compound of Formula 2 and compound of Formula 3 in the presence of a solvent to Form compound of Formula 4, which on removal of the protecting groups forms compound of Formula 1.

QUINOLINE-2-ONE-DERIVATIVES FOR THE TREATMENT OF AIRWAYS DISEASES

Compounds of formula (I) in free or salt form, wherein -C-Y-, R1 and R2 are G have the meanings as indicated in the specification, are useful for treating conditions that are prevented or alleviated by activation of the (β2-adrenoreceptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.