4441-15-0

Basic information

• Product Name: Morpholin-2-one
• Synonyms: Morpholin-2-one;2-Morpholinone;Morpholin-2-one hcl;morpholin-2-one hydrochloride
• CAS NO: 4441-15-0
• Molecular Formula: C₄H₇NO₂
• Molecular Weight: 101.10388
• Mol File: 4441-15-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 178℃
• Boiling Point: 258.6±33.0℃ (760 Torr)
• Flash Point: 110.2±25.4℃
• Appearance: /
• Density: 1.122±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.014mmHg at 25°C
• Refractive Index: 1.436
• PKA: 6.89±0.20(Predicted)
• CAS DataBase Reference: Morpholin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholin-2-one(4441-15-0)
• EPA Substance Registry System: Morpholin-2-one(4441-15-0)

Safety Data

• Hazardous Substances Data: 4441-15-0(Hazardous Substances Data)

Usage

General Description

Morpholin-2-one, also known as 2-Oxomorpholine, is a chemical compound with the formula C4H5NO2. It belongs to the class of organic compounds called morpholinones that contain a morpholine ring bearing a ketone. It's a colorless liquid and is categorized as an organopollutant and an organooxygen compound. Morpholin-2-one is generally used in the synthesis of other compounds, including pharmaceutical intermediates. Morpholin-2-one is not typically used directly, but its derivatives have potential applications in medicine and chemistry.

InChI:InChI=1/C4H7NO2/c6-4-3-5-1-2-7-4/h5H,1-3H2

Upstream product

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Downstream Products

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Relevant articles and documents

2 - Morpholine alkone salt and its preparation method, 2 - process for preparation of method (by machine translation)

The invention relates to a 2 - morpholine alkone salt and its preparation method, 2 - process for preparation of method, which belongs to the technical field of the synthesis of pharmaceutical intermediates. The 2 - morpholine alkone salt preparation method, comprises the following steps: the amino protecting group with N - (2 - hydroxyethyl) glycine, catalyst in the reflux solvent heating reflux reaction, with amino protecting group prepared 2 - morpholone; said catalyst is paratoluene sulfonic acid or concentrated sulfuric acid; the amino protecting group with 2 - morpholone acidification is carried out by removing the protecting group 2 - morpholine alkone salt. 2 - Morpholone is 2 - morpholine alkone salt in the solvent in the reaction with the alkali. The invention of 2 - morpholine alkone salt and 2 - morpholone in the preparation method, the use of cheap raw material, short synthetic route, all reaction intermediate and final products do not need column chromatographic purification. The method of low cost, high efficiency, and high product purity. (by machine translation)

Triazolium Carbene Catalysts and Stereoselective Bond Forming Reactions Thereof

Provided herein are triazolium carbine catalysts useful for asymmetric hydration, fluorination, and deuteration, and processes for their preparation. Also provided are synthetic reactions in which these catalysts are used, in particular, in stereoselective formation of carbon-chlorine, carbon-hydrogen, carbon-fluorine, and carbon-deuterium bonds.

Piperizinones as modulators of chemokine receptor activity

The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.