4442-17-5Relevant articles and documents
Site-selective oxidation, amination and epimerization reactions of complex polyols enabled by transfer hydrogenation
Hill, Christopher K.,Hartwig, John F.
, p. 1213 - 1221 (2017/11/28)
Polyoxygenated hydrocarbons that bear one or more hydroxyl groups comprise a large set of natural and synthetic compounds, often with potent biological activity. In synthetic chemistry, alcohols are important precursors to carbonyl groups, which then can be converted into a wide range of oxygen- or nitrogen-based functionality. Therefore, the selective conversion of a single hydroxyl group in natural products into a ketone would enable the selective introduction of unnatural functionality. However, the methods known to convert a simple alcohol, or even an alcohol in a molecule that contains multiple protected functional groups, are not suitable for selective reactions of complex polyol structures. We present a new ruthenium catalyst with a unique efficacy for the selective oxidation of a single hydroxyl group among many in unprotected polyol natural products. This oxidation enables the introduction of nitrogen-based functional groups into such structures that lack nitrogen atoms and enables a selective alcohol epimerization by stepwise or reversible oxidation and reduction.
Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding
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, (2008/06/13)
Fluorescence immunoassays methods are provided which use fluorescent dyes which are free of aggregation and serum binding. Such immunoassay methods are thus, particularly useful for the assay of biological fluids, such as serum, plasma, whole blood and urine.
Rearrangement of 14β-Hydroxy-12β-sulfoxy-steroids to 13,17-Seco-12,17-cyclo-steroids; a 2D-NMR Analysis
Habermehl, Gerhard G.,Hammann, Peter E.
, p. 656 - 660 (2007/10/02)
The rearrangement of 3-oxo-14β-hydroxy-12β-methanesulfoxy-card-20(22)-enolide and 14β-hydroxy-12β-methanesulfoxy-pregnane-3,20-dione during elimination of the sulfoxygroups was studied.By means of 2D-NMR analysis the structures were determined as 13,17-seco-12,17-cyclo-steroids. - Keywords: 13,17-Decyclo-12,17-cyclosteroids, Steroid Rearrangement, NMR Spectra