4443-09-8

Basic information

• Product Name: 5,7,8-TRIHYDROXYFLAVONE
• Synonyms: 2-phenyl-5,7,8-trihydroxy-4h-1-benzopyran-4-on;2-phenyl-5,7,8-trihydroxy-4h-1-benzopyran-4-one;5,7,8-trihydroxy-flavon;NORWOGONIN;TRIHYDROXYFLAVONE, 5,7,8-;5,7,8-TRIHYDROXYFLAVONE;TRIHYDROXYFLAVONE, 5,7,8-(RG);5,7,8-HYDROXYFLAVONE
• CAS NO: 4443-09-8
• Molecular Formula: C₁₅H₁₀O₅
• Molecular Weight: 270.24
• Product Categories: Tri-substituted Flavones
• Mol File: 4443-09-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 227-228 °C
• Boiling Point: 528.4°C at 760 mmHg
• Flash Point: 206°C
• Appearance: /
• Density: 1.548g/cm³
• Vapor Pressure: 8.78E-12mmHg at 25°C
• Refractive Index: 1.732
• PKA: 6.66±0.40(Predicted)
• CAS DataBase Reference: 5,7,8-TRIHYDROXYFLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7,8-TRIHYDROXYFLAVONE(4443-09-8)
• EPA Substance Registry System: 5,7,8-TRIHYDROXYFLAVONE(4443-09-8)

Safety Data

• Hazardous Substances Data: 4443-09-8(Hazardous Substances Data)

Usage

Definition

ChEBI: A trihydroxyflavone with the hydroxy groups at positions C-5, -7 and -8.

InChI:InChI=1/C15H10O5/c16-9-6-11(18)14(19)15-13(9)10(17)7-12(20-15)8-4-2-1-3-5-8/h1-7,16,18-19H

Upstream product

• 480-40-0 5,7-dihydroxy-2-phenyl-chromen-4-one 
• 97080-93-8 1-phenyl-3-(2,3,4,6-tetramethoxy-phenyl)-propane-1,3-dione 
• 3316-54-9 7-hydroxy-5,8-dimethoxyflavone 
• 5333-45-9 1,2,3,5-tetramethoxybenzene 
• 4431-47-4 5,8-dihydroxy-7-methoxyflavone 
• 21392-57-4 Dimethyl-chrysin 
• 42079-76-5 5,7-dimethoxy-8-bromo-flavone 
• 137790-18-2 5,7-bis(benzyloxy)-2-phenyl-4H-chromen-4-one 
• 120979-97-7 (E)-1-(2,4-bis(benzyloxy)-6-hydroxyphenyl)-3-phenylprop-2-en-1-one 
• 100-52-7 benzaldehyde 
• 18065-05-9 1-[2,4-bis(benzyloxy)-6-hydroxyphenyl]ethanone 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 857564-84-2 1-(2,4-bis-benzoyloxy-3,6-dimethoxy-phenyl)-ethanone 
• 108-73-6 3,5-dihydroxyphenol 

Downstream Products

• 146195-87-1 6-C-(3,3-dimethyl-2-propen-1-yl)norwogonin 
• 146195-88-2 7-O-(3,3-dimethyl-2-propen-1-yl)norwogonin 
• 3570-62-5 5-hydroxy-7,8-dimethoxyflavone 
• 4431-47-4 5,8-dihydroxy-7-methoxyflavone 
• 632-85-9 wogonin 
• 109805-38-1 7,8-diacetoxy-5-methoxy-2-phenyl-chromen-4-one 
• 641-55-4 7,8-dihydroxy-5-methoxy-2-phenyl-chromen-4-one 
• 137231-92-6 Scutellaprostin A triacetate 
• 23050-38-6 5,7,8-trimethoxy-2-phenyl-chromen-4-one 
• 94879-97-7 5,7,8-triacetoxy-2-phenyl-chromen-4-one 
• 110515-94-1 7,8-diacetoxy-5-hydroxy-2-phenyl-chromen-4-one 
• 109309-41-3 5-hydroxy-7,8-dimethoxy-6-methyl-2-phenyl-chromen-4-one 

Relevant articles and documents

[...] flavone, [...] baicalin and to a method for synthesizing Chinese baicalin

The present invention discloses a moslosooflavone synthetic method. The method comprises the steps of (1) 5,7-dimethoxy-8-bromo-flavone is reacted with sodium methylate under the catalysis of a copper salt to generate 5,7,8-trimethoxy flavone; (2) in an i

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An expeditious synthesis of norwogonin, isoscutellarein, and herbacetin, has been accomplished by a strategy featuring a borylation of sterically hindered aryl iodide and a one-pot oxidation to generate the C-3 and C-8 OH groups. The total synthesis gives excellent yields and conventional flash column chromatography is not needed for purification.