18065-05-9

Basic information

• Product Name: 1-(2,4-bis (benzyloxy)-6-hydroxyphenyl) ethanone
• Synonyms: 1-(2,4-bis (benzyloxy)-6-hydroxyphenyl) ethanone;2-Acetyl-3,5-bis(benzyloxy)phenol
• CAS NO: 18065-05-9
• Molecular Formula: C₂₂H₂₀O₄
• Molecular Weight: 348.3918
• Mol File: 18065-05-9.mol
• Article Data: 47

Chemical Properties

• Melting Point: 108-109 °C(Solv: methanol (67-56-1))
• Boiling Point: 550.4 °C at 760 mmHg
• Flash Point: 194.4 °C
• Appearance: /
• Density: 1.206 g/cm³
• Vapor Pressure: 1E-12mmHg at 25°C
• Refractive Index: 1.612
• PKA: 9.41±0.15(Predicted)
• CAS DataBase Reference: 1-(2,4-bis (benzyloxy)-6-hydroxyphenyl) ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-bis (benzyloxy)-6-hydroxyphenyl) ethanone(18065-05-9)
• EPA Substance Registry System: 1-(2,4-bis (benzyloxy)-6-hydroxyphenyl) ethanone(18065-05-9)

Safety Data

• Hazardous Substances Data: 18065-05-9(Hazardous Substances Data)

Usage

Uses

1-(2,4-bis(Benzyloxy)-6-hydroxyphenyl)ethanone is a useful reactant for the synthesis of fluorine-containing chalcone derivatives that have antiproliferative activity.

Preparation

Preparation by reaction of benzyl chloride on phloroacetophenone with potassium carbonate in refluxing acetone (29%), (20%), in DMF at 100° (54%) and at 150–153° (26%) or in HMPA at 90–93° (80%).

InChI:InChI=1/C22H20O4/c1-16(23)22-20(24)12-19(25-14-17-8-4-2-5-9-17)13-21(22)26-15-18-10-6-3-7-11-18/h2-13,24H,14-15H2,1H3

Upstream product

• 39548-86-2 1‐(2‐(benzyloxy)‐4,6‐dihydroxyphenyl)ethan‐1‐one 
• 100-44-7 benzyl chloride 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 17820-33-6 acetic acid 5-acetoxy-2-acetyl-3-hydroxyphenyl ester 
• 100-39-0 benzyl bromide 
• 115623-29-5 2-benzyloxy-4,6-bis(methoxymethyloxy)acetophenone 
• 65490-09-7 2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone 
• 480-40-0 5,7-dihydroxy-2-phenyl-chromen-4-one 
• 108-73-6 3,5-dihydroxyphenol 
• 59434-20-7 1,3,5-tri-O-benzylphloroglucinol 
• 2999-40-8 1,3,5-triacetoxybenzene 
• 61497-71-0 1-(2,4,6-tris(benzyloxy)phenyl)ethan-1-one 
• 584-08-7 potassium carbonate 
• 137790-18-2 5,7-bis(benzyloxy)-2-phenyl-4H-chromen-4-one 

Downstream Products

• 62252-08-8 4',6'-bis(benzyloxy)-2'-hydroxy-3,4,5-trimethoxychalcone 
• 132018-00-9 methyl 3-<4,6-bis(benzyloxy)-2-hydroxyphenyl>-3-oxopropanoate 
• 132018-01-0 ethyl 3-<4,6-bis(benzyloxy)-2-hydroxyphenyl>-3-oxopropanoate 
• 250273-70-2 4-acetyl-1,5-dibenzyloxy-3-hydroxy-2-C-(2,3,4,6-tetra-O-benzyl-β-D-mannopyranosyl)benzene 
• 906653-32-5 1-(2’,4’-dibenzyloxy-6’-hydroxyphenyl)-2-hydroxyethanone 
• 120980-04-3 (E)-1-(2,4-bis(benzyloxy)-6-hydroxyphenyl)-3-(3',4'-bis(benzyloxy)phenyl)prop-2-en-1-one 
• 906653-33-6 1-(2',4'-dibenzyloxy-6'-hydroxyphenyl)-2-(2'',3'',4'',6''-tetra-O-benzyl-β-D-glucopyranosyloxy)ethanone 
• 906653-35-8 1-[2'-(3'',4''-diallyloxy[carbonyl-13C]benzyloxy)-4',6'-dibenzyloxyphenyl]-2-(2''',3''',4''',6'''-tetra-O-benzyl-β-D-glucopyranosyloxy)ethanone 
• 110506-85-9 7-(benzyloxy)-5-hydroxy-2-phenyl-4H-chromen-4-one 
• 7480-94-6 Luteolin-8-C-glucoside 
• 381686-08-4 2-(3,4-bis-benzyloxyphenyl)-7-benzyloxy-8-C-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-5-methoxy-4H-1-benzopyran-4-one 
• 381686-07-3 2-(3,4-bis-benzyloxyphenyl)-7-benzyloxy-8-C-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-5-hydroxy-4H-1-benzopyran-4-one 
• 381686-06-2 3,4,4',6'-tetrakis-benzyloxy-3'-C-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-2'-hydroxychalcone 

Relevant articles and documents

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